Coordonnées
Institut de Cardiologie de Montréal
T 514 376-3330#2476
F 514 412-7591
adnane.sellam@umontreal.ca
Axes de recherche
- Biologie des systèmes
- Approches thérapeutiques
- Génomique
- Signalisation intracellulaire
Description de la recherche
Le but du programme de recherche du groupe de Dr Sellam est de comprendre d’une manière approfondie les différents aspects de la biologie des champignons opportunistes notamment, Candida albicans et la levure « super-résistante » C. auris, afin de proposer de nouvelles cibles thérapeutiques. Trois thématiques principales de recherche sont actuellement investiguées :
- Influence de l’hypoxie sur le pouvoir pathogène et le fitness métabolique fongiques.
- Découverte de nouvelles molécules antifongiques.
- Control de la coordination entre la croissance (biomasse) et de la division cellulaire chez les eucaryotes.
Research axis
- Systems biology
- Therapeutic approaches
- Genomics
- Intracellular signaling
Research description
The main objective of Dr Sellam’s research is to gain a deep knowledge on mechanisms that control the virulence of the major human fungal pathogens Candida albicans and the superbug C. auris. This will lead to the identification of proteins or biological processes that could be targeted for antifungal therapeutics. Three different research axes are being currently investigated:
- Impact of hypoxia on fungal virulence and metabolic fitness
- Discovery of novel antifungal therapeutics
- Coordination of growth and division in eukaryotic organisms
Publications
- Burgain A, Tebbji F, Khemiri I and Sellam A (2020) Metabolic reprogramming in the opportunistic yeastCandida albicans in response to hypoxia. mSphere, 5:e00913-19 (PMID: 32102943).
- Burgain A, Pic E, Markey L, Tebbji F, Kumamoto C and Sellam A (2019) A Novel Genetic Circuitry Governing Hypoxic Metabolic Flexibility, Commensalism and Virulence in the Fungal PathogenCandida albicans. PLoS Pathogens, 15(12): e1007823 (PMID:31809527).
- Sellam A, Chaillot J, Mallick J, Cook MA, Tebbji F and Tyers M(2019) The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans. PLoS Genetics, 15(3): e1008052 (PMID: 30921326).
- García C, Tebbji F, Daigneault M, Liu N, Köhler JR, Allen-Vercoe E andSellam A (2017) The human gut microbial metabolome modulates fungal growth via TOR signaling pathway. mSphere, 2(6) e00555-17 (PMID: 29242837).
- Ryan O, Shapiro R, Kurat C, MayhewD, Baryshnikova A, Chin B, Lin ZL, Cox M, Vizeacoumar F, Cheung D, Bahr S, Tsui K, Tebbji F, Sellam A et al. (2012) Global Gene Deletion Analysis Exploring Yeast Filamentous Growth. Science. 337(6100):1353-56 (PMID: 22984072).