Coordonnées
Centre de recherche
Hôpital Maisonneuve-Rosemont
T 514 252-3400 #4665
F 514 252-3430
elliot.drobetsky@umontreal.ca
Axes de recherche
- Signalisation intracellulaire
- Cancérologie
Description de la recherche
Mon laboratoire étudie actuellement les voies de signalisation cellulaire humaines impliquées dans le maintien de la stabilité génomique. Nous nous concentrons principalement sur la lumière UV comme modèle mutagène. Ces études sont primordiales pour l’amélioration de notre compréhension à savoir comment le cancer se développe, en particulier le mélanôme malin. Par ailleurs, puisque de nombreux agents chimiothérapeutiques tuent sélectivement les cellules tumorales en endommageant leur ADN, notre recherche a des implications cruciales pour le traitement du cancer.
Research axis
- Intracellular signaling
- Cancer
Research description
The research themes:
- Cellular responses to DNA damage in human cells
- Role of DNA repair in cancer development and treatment
My laboratory is currently investigating human cellular signaling pathways involved in the maintenance of the genomic stability. We are focusing primarily on UV light as model mutagen. Such studies are critical towards enhancing our understanding of how cancer (particularly malignant melanoma) is induced by various ubiquitous environmental genotoxins. Moreover, since many chemotherapeutic agents selectively kill tumour cells by damaging their DNA, our research has critical implications for cancer treatment.
Publications
- Drobetsky, E.A., A.J. Grosovsky, and B.W. Glickman. (1987) The specificity of UV-induced mutations at an endogenous locus in mammalian cells. Proc. Natl. Acad. Sci., 84: 9103-9107.
- Drobetsky, E.A.,Turcotte, J., and Chateauneuf, A. (1995). A role for ultraviolet-A in solar mutagenesis, Proc. Natl. Acad. Sci. 92:2350-2354.
- Sage, E., Lamolet, B., Brulay, E., Moustacchi, E., Chateauneuf, A. and Drobetsky, E.A. (1996). The mutagenic specificity of solar ultraviolet light in nucleotide excision repair-deficient rodent cells. Proc. Natl. Acad. Sci. 93:176-180.
- Mathonnet, G., Léger, C., Desnoyers, J., Drouin, R., Therrien, J.P., and Drobetsky, E.A. (2003). UV Wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells. Proc. Natl. Acad. Sci. 100:7219-7224. .
- Auclair, Y., Rouget, R., Affar, E.B., and Drobetsky, E.A. (2008) ATR kinase is required for global nucleotide excision repair exclusively during S phase in human cells, Proc. Natl. Acad. Sci. 105:17896-17901.