Professeur et Chaire de recherche du Canada en protéomique
Coordonnées
Département de chimie et
Institut de Recherche en Immunologie et Cancérologie
Université de Montreal
C.P. 6128, Station Centre-ville
Montreal (Québec) H3C 3J7
T 514 343-6910
F 514 343-6843
pierre.thibault@umontreal.ca
Axes de recherche
- Signalisation intracellulaire
- Immunologie et Hématopoïèse
- Protéomique
- Biologie des systèmes
Description de la recherche
Notre programme de recherche porte principalement dans l’application de la protéomique et de la spectrométrie de masse bioanalytique dans le but d’obtenir une meilleure compréhension des processus cellulaires tels la biogenèse d’organites (phagolysosome et endosome), la signalisation (phosphorylation et sumoylation) chez les cellules cancéreuses ou encore l’identification de peptides issus de complexes majeur d’histocompatibilité.
Research axis
- Intracellular signaling
- Immunology and haematopoiesis
- Proteomic
- Systems biology
Research description
Our research program is focused primarily on the application of proteomics and bioanalytical mass spectrometry to gain further insights to complex cell biology paradigms such as organelle biogenesis (phagosome and endosome), cell signaling (phosphorylation and sumoylation) in cancer, and the identification of peptides presented by the major histocompatibility complex proteins.
Publications
- E. Caron, K. Vincent, M.-H. Fortier, J.-P. Laverdure, A. Bramoullé, M.-P. Hardy, G. Voisin, P.P. Roux, S. Lemieux, P. Thibault, C. Perreault, “The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation”, Mol. Syst. Biol., in press
- F. Galisson, L. Mahrouche, M. Courcelles, E. Bonneil, S. Meloche, M. K. Chelbi-Alix, P. Thibault, “A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells, Mol Cell. Proteomics, 10, M110.004796 (2011).
- M. Trost, L. English, M. Courcelles, M. Desjardins, P. Thibault, “Deciphering the Phagosomal Proteome in Interferon-g Activated Macrophages”, Immunity, 30, 143-154 (2009).
- M.-H. Fortier, E. Caron, M.-P. Hardy, G. Voisin, S. Lemieux, C. Perreault, P. Thibault, “The MHC I immunopeptidome is moulded by the transcriptome”, J. Exp. Med., 205, 595-610 (2008).
- M. Marcantonio, M. Trost, M. Courcelles, M. Desjardins, P. Thibault, “Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses; application to cell signaling events of interferon-γ stimulated macrophages”, Mol Cell Proteomics, 7, 645-660 (2008).