{"id":5628,"date":"2023-03-21T13:35:28","date_gmt":"2023-03-21T17:35:28","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/?page_id=5628"},"modified":"2023-03-21T16:38:57","modified_gmt":"2023-03-21T20:38:57","slug":"rashkovan-marissa-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/","title":{"rendered":"Rashkovan, Marissa, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Chercheuse, Axe maladies immunitaires et cancers
\nCentre de Recherche du CHU Sainte-Justine, Montr\u00e9al
\nProfesseur-chercheure adjoint, Dept. Pathologie et Biologie cellulaire, Universit\u00e9 de Montr\u00e9al<\/p>\n

T\u00e9l\u00a0: 514 345-4931 poste 2448<\/p>\n

Marissa.rashkovan@umontreal.ca<\/a><\/p>\n

www.Rashkovanlab.com<\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Immunologie et h\u00e9matopo\u00ef\u00e8se<\/li>\n
  • Canc\u00e9rologie<\/li>\n
  • Approches th\u00e9rapeutiques<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Notre recherche se concentre sur l’\u00e9tude du m\u00e9tabolisme de la leuc\u00e9mie lymphoblastique aigu\u00eb des cellules T (LLA-T). Pour \u00e9tudier les changements m\u00e9taboliques dans ces leuc\u00e9mies et l’interaction des voies m\u00e9taboliques avec l’\u00e9pig\u00e9nome et les voies de signalisation cellulaire, nous utilisons des techniques de biologie mol\u00e9culaire et cellulaire, y compris la cytom\u00e9trie de flux, la culture cellulaire de lign\u00e9es leuc\u00e9miques et de cellules primaires de patients, l’analyse des prot\u00e9ines, les cribles CRISPR, les \u00e9tudes pharmacodynamiques in vitro <\/em>et in vivo<\/em>, RNAseq, ATACseq et ChIPseq. Notre objectif est de caract\u00e9riser les changements m\u00e9taboliques qui se produisent au cours du d\u00e9veloppement de la LLA-T, afin de d\u00e9velopper de nouvelles th\u00e9rapies et de nouveaux traitements pour les patients atteints de cette maladie.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Immunology and hematopoiesis<\/li>\n
    • Cancer research<\/li>\n
    • Therapeutic approaches<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      Our research focuses on studying the metabolism of T-cell acute lymphoblastic leukemia (T-ALL). To study the metabolic changes in these leukemias, and the interaction of metabolic pathways with the epigenome and cellular signaling pathways, we use a wide array of molecular and cellular biology techniques including flow cytometry, cell culture of leukemic lines and primary patient cells, protein analysis, CRISPR screens, in vitro<\/em> and in vivo<\/em> pharmacodynamic studies, RNAseq, ATACseq and ChIPseq. Our goal is to characterize the metabolic changes that occur during the development of T-ALL, in order to develop novel therapies and treatments for patients with this disease.<\/p>\n<\/div>\n\n

      Publications<\/h3>\n
        \n
      • Rashkovan, M<\/strong>, Albero, R, Gianni, F, Perez-Duran, P, Miller, HI, Mackey, AL, Paietta, EM, Tallman, MS, Rowe, JM, Litzow, MR, Wiernik, PH, Luger, S, Sulis, ML, Soni, RK, Ferrando, AA. Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia. Cancer Discovery. 2022 Mar 1;12(3):856-871. doi: 10.1158\/2159-8290.CD-21-0551. PMID: 34711640<\/li>\n
      • Rashkovan, M<\/strong>, and Ferrando, AA (2019). Metabolic dependencies and vulnerabilities in leukemia. Genes and Development. 33.<\/li>\n
      • Ross J*, Rashkovan M*<\/strong>, Fraszczak J, Joly Beauparlant C, Vadnais C, Winkler R, Droit A, Kosan C, M\u00f6r\u00f6y T (2019). Deletion of the Miz-1 POZ domain increases efficacy of cytarabine treatment in T- and B-ALL\/lymphoma mouse models. Cancer Research. August 15 2019 (79) (16) 4184-4195.<\/li>\n
      • Rashkovan, M<\/strong>, Vadnais, C, Ross, J, Gigoux, M, Suh, WK, Gu, W, Kosan, C, M\u00f6r\u00f6y, T (2014). Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination. Proc. Natl. Acad. Sci. USA. 111(50): E5411-E5419.<\/li>\n<\/ul>\n

         <\/p>\n","protected":false},"excerpt":{"rendered":"

        Coordonn\u00e9es Chercheuse, Axe maladies immunitaires et cancers Centre de Recherche du CHU Sainte-Justine, Montr\u00e9al Professeur-chercheure adjoint, Dept. Pathologie et Biologie cellulaire, Universit\u00e9 de Montr\u00e9al T\u00e9l\u00a0: 514 345-4931 poste 2448 Marissa.rashkovan@umontreal.ca […]<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5628","page","type-page","status-publish","hentry"],"yoast_head":"\nRashkovan, Marissa, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rashkovan, Marissa, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Chercheuse, Axe maladies immunitaires et cancers Centre de Recherche du CHU Sainte-Justine, Montr\u00e9al Professeur-chercheure adjoint, Dept. Pathologie et Biologie cellulaire, Universit\u00e9 de Montr\u00e9al T\u00e9l\u00a0: 514 345-4931 poste 2448 Marissa.rashkovan@umontreal.ca […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-21T20:38:57+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/\",\"name\":\"Rashkovan, Marissa, Ph.D. - Programmes de biologie mol\u00e9culaire\",\"isPartOf\":{\"@id\":\"https:\/\/biomol.umontreal.ca\/#website\"},\"datePublished\":\"2023-03-21T17:35:28+00:00\",\"dateModified\":\"2023-03-21T20:38:57+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Rashkovan, Marissa, Ph.D.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/biomol.umontreal.ca\/#website\",\"url\":\"https:\/\/biomol.umontreal.ca\/\",\"name\":\"Programmes de biologie mol\u00e9culaire\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/biomol.umontreal.ca\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rashkovan, Marissa, Ph.D. - Programmes de biologie mol\u00e9culaire","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/biomol.umontreal.ca\/en\/rashkovan-marissa-ph-d\/","og_locale":"en_US","og_type":"article","og_title":"Rashkovan, Marissa, Ph.D. - Programmes de biologie mol\u00e9culaire","og_description":"Coordonn\u00e9es Chercheuse, Axe maladies immunitaires et cancers Centre de Recherche du CHU Sainte-Justine, Montr\u00e9al Professeur-chercheure adjoint, Dept. 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