{"id":5608,"date":"2023-02-22T14:31:08","date_gmt":"2023-02-22T19:31:08","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/"},"modified":"2023-02-22T14:31:08","modified_gmt":"2023-02-22T19:31:08","slug":"tanaka-yoshiaki-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/","title":{"rendered":"Tanaka, Yoshiaki, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Centre de recherche H\u00f4pital Maisonneuve Rosemont
\n5415, boulevard de l\u2019Assomption
\nMontr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada
\nT\u00a0: 514 252-3400 #7052
\nT (labo)\u00a0: 514 252-3400 #6899<\/p>\n

yoshiaki.tanaka@umontreal.ca<\/a>\u00a0<\/strong><\/p>\n

https:\/\/crhmr.ciusss-estmtl.gouv.qc.ca\/fr\/chercheur\/yoshiaki-tanaka<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Bio-informatique<\/li>\n
  • Cellules souches<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Le glioblastome multiforme (GBM) est la tumeur maligne du cerveau la plus commune et la plus difficile \u00e0 soigner par les options de traitement actuelles. L\u2019information g\u00e9n\u00e9tique du GBM telle que l\u2019ARN et la chromatine est importante, non seulement pour r\u00e9v\u00e9ler les m\u00e9canismes mol\u00e9culaires de la progression du cancer mais aussi pour d\u00e9couvrir de nouvelles cibles de m\u00e9dicaments et ainsi d\u00e9velopper de nouvelles th\u00e9rapies dans le futur.\u00a0 Toutefois, il reste des incertitudes pour savoir comment ces caract\u00e9ristiques g\u00e9n\u00e9tiques (ex. l\u2019expression de l\u2019ARN, les modifications de la chromatine) contribuent \u00e0 la progression des tumeurs et aux r\u00e9sultats cliniques. Notre vision de recherche \u00e0 long terme a pour but de clarifier les m\u00e9canismes mol\u00e9culaires de la progression des tumeurs du cerveau et l\u2019association des caract\u00e9ristiques g\u00e9n\u00e9tiques avec les ph\u00e9notypes des patients. Pour atteindre cet objectif, notre laboratoire utilise :\u00a0 1) un syst\u00e8me de culture en 3D d\u2019organo\u00efdes et de sph\u00e9ro\u00efdes de cerveaux humains et 2) une technique bio-informatique pour extraire des informations biologiquement significatives \u00e0 partir des donn\u00e9es g\u00e9n\u00e9tiques complexes.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Bioinformatics<\/li>\n
    • Stem Cells<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      Glioblastoma multiforme (GBM) is the most common malignant brain tumor and very hard to be cured by current treatment options. Genetic information of GBM, such as RNA and chromatin, is important not only to reveal molecular mechanisms of cancer growth, but also find out new drug targets for future therapeutic development. However, it remains unclear how these genetic features (e.g. RNA expression, chromatin modifications) contribute to tumor progression and clinical outcome. Our long-term research vision aims to clarify molecular mechanisms of brain tumor progression and association of the genetic features with patients’ phenotypes. To achieve this goal, our lab utilizes 1) 3D culture system of human brain organoids and spheroids and 2) bioinformatics technique to extract biologically-meaningful information from the complex genetic datasets.<\/p>\n<\/div>\n\n

      Publications<\/h3>\n
        \n
      • Tanaka<\/strong>, B. Cakir, Y. Xiang, G.J. Sullivan and I.H. Park, Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain. Cell Reports<\/em>, 2020, 30: 1682-1689.e3<\/li>\n
      • Xiang*, Y. Tanaka*<\/strong>, B. Patterson, S.-M. Hwang, E. Hysolli, B. Cakir, K.-Y. Kim, W. Wang, Y.-J. Kang, E. M. Clement, M. Zhong, S.-H. Lee, Y. S. Cho, P. Patra, G. J. Sullivan, S. M. Weissman, I.-H. Park, Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons, Mol. Cell<\/em>, 2020, 79(1):84-98.e9<\/li>\n
      • Xiang*, Y. Tanaka*<\/strong>, B. Cakir, B. Patterson, K.Y. Kim, P. Sun, Y.J. Kang, M. Zhong, X. Liu, P. Patra, S.H. Lee, S.M. Weissman, I.H. Park, hESC-derived thalamic organoids form reciprocal projections when fused with cortical organoids. Cell Stem Cell<\/em>, 2019, 24: 487-497.e7. *Equal contribution<\/li>\n
      • Xiang*, Y. Tanaka*<\/strong>, B. Patterson, Y.J. Kang, G. Govindaiah, N. Roselaar, B. Cakir, K.Y. Kim, A.P. Lombroso, S.M. Hwang, M. Zhong, E.G. Stanley, A.G. Elefanty, J.R. Naegele, S.H. Lee, S.M. Weissman, I.H. Park, Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration. Cell Stem Cell<\/em>, 2017, 21: 383-398.e7. *Equal contribution<\/li>\n
      • Cakir*, Y. Tanaka*<\/strong>, F. R. Kiral, Y. Xiang, O. Dagliyan, J. Wang, M. Lee, A.M. Greaney, W.S. Yang, C. duBoulay, M.H. Kural, B. Patterson, M. Zhong, J. Kim, Y. Bai, W. Ming, L.E. Niklason, P. Patra, and I.H. Park., Human cortical organoids with functional microglial-like cells provide a tractable model for Alzheimer\u2019s Disease, Nature Communications<\/em>, 13: 1. *Equal contribution<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        Coordonn\u00e9es Centre de recherche H\u00f4pital Maisonneuve Rosemont 5415, boulevard de l\u2019Assomption Montr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada T\u00a0: 514 252-3400 #7052 T (labo)\u00a0: 514 252-3400 #6899 yoshiaki.tanaka@umontreal.ca\u00a0 https:\/\/crhmr.ciusss-estmtl.gouv.qc.ca\/fr\/chercheur\/yoshiaki-tanaka Publications Tanaka, B. […]<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5608","page","type-page","status-publish","hentry"],"yoast_head":"\nTanaka, Yoshiaki, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tanaka, Yoshiaki, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Centre de recherche H\u00f4pital Maisonneuve Rosemont 5415, boulevard de l\u2019Assomption Montr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada T\u00a0: 514 252-3400 #7052 T (labo)\u00a0: 514 252-3400 #6899 yoshiaki.tanaka@umontreal.ca\u00a0 https:\/\/crhmr.ciusss-estmtl.gouv.qc.ca\/fr\/chercheur\/yoshiaki-tanaka Publications Tanaka, B. […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/\",\"name\":\"Tanaka, Yoshiaki, Ph.D. - Programmes de biologie mol\u00e9culaire\",\"isPartOf\":{\"@id\":\"https:\/\/biomol.umontreal.ca\/#website\"},\"datePublished\":\"2023-02-22T19:31:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Our professors\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Tanaka, Yoshiaki, Ph.D.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/biomol.umontreal.ca\/#website\",\"url\":\"https:\/\/biomol.umontreal.ca\/\",\"name\":\"Programmes de biologie mol\u00e9culaire\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/biomol.umontreal.ca\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tanaka, Yoshiaki, Ph.D. - Programmes de biologie mol\u00e9culaire","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/","og_locale":"en_US","og_type":"article","og_title":"Tanaka, Yoshiaki, Ph.D. - Programmes de biologie mol\u00e9culaire","og_description":"Coordonn\u00e9es Centre de recherche H\u00f4pital Maisonneuve Rosemont 5415, boulevard de l\u2019Assomption Montr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada T\u00a0: 514 252-3400 #7052 T (labo)\u00a0: 514 252-3400 #6899 yoshiaki.tanaka@umontreal.ca\u00a0 https:\/\/crhmr.ciusss-estmtl.gouv.qc.ca\/fr\/chercheur\/yoshiaki-tanaka Publications Tanaka, B. […]","og_url":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/","og_site_name":"Programmes de biologie mol\u00e9culaire","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/","url":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/","name":"Tanaka, Yoshiaki, Ph.D. - Programmes de biologie mol\u00e9culaire","isPartOf":{"@id":"https:\/\/biomol.umontreal.ca\/#website"},"datePublished":"2023-02-22T19:31:08+00:00","breadcrumb":{"@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/tanaka-yoshiaki-ph-d\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/biomol.umontreal.ca\/en\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/biomol.umontreal.ca\/en\/research\/"},{"@type":"ListItem","position":3,"name":"Our professors","item":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/"},{"@type":"ListItem","position":4,"name":"Tanaka, Yoshiaki, Ph.D."}]},{"@type":"WebSite","@id":"https:\/\/biomol.umontreal.ca\/#website","url":"https:\/\/biomol.umontreal.ca\/","name":"Programmes de biologie mol\u00e9culaire","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/biomol.umontreal.ca\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/5608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/users\/216"}],"replies":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/comments?post=5608"}],"version-history":[{"count":0,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/5608\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3557"}],"wp:attachment":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/media?parent=5608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}