{"id":5598,"date":"2022-12-02T16:25:36","date_gmt":"2022-12-02T21:25:36","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/les-professeurs\/lecuyer-eric-ph-d\/"},"modified":"2022-12-02T16:25:50","modified_gmt":"2022-12-02T21:25:50","slug":"lecuyer-eric-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/lecuyer-eric-ph-d\/","title":{"rendered":"L\u00e9cuyer, \u00c9ric, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRCM<\/p>\n

514 987-5646
\neric.lecuyer@ircm.qc.ca<\/a><\/p>\n

Sites web du labo\u00a0:<\/strong><\/p>\n

https:\/\/www.ircm.qc.ca\/en\/researchers\/eric-lecuyer<\/a> (site IRCM)<\/p>\n

https:\/\/www.lecuyerlab.org\/<\/a> (personnel)<\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • G\u00e9nomique<\/li>\n
  • Bioinformatique<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n
  • Biologie des syst\u00e8mes<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Le transport intracellulaire des ARNm, combin\u00e9 \u00e0 leur traduction localis\u00e9e, repr\u00e9sente un m\u00e9canisme exquis pour contr\u00f4ler l\u2019organisation cellulaire et le ciblage des modules prot\u00e9iques. Ce m\u00e9canisme joue un r\u00f4le important dans une vari\u00e9t\u00e9 de processus biologiques, incluant la sp\u00e9cification des axes embryonnaires durant le d\u00e9veloppement, la migration et l\u2019adh\u00e9sion cellulaire, et la division cellulaire asym\u00e9trique. Des \u00e9tudes g\u00e9nomiques r\u00e9centes sugg\u00e8rent que la localisation des ARNm repr\u00e9sente un processus hautement pr\u00e9valent, qui pourrait jouer un r\u00f4le majeur dans l\u2019organisation cellulaire. Notre laboratoire s\u2019int\u00e9resse \u00e0 \u00e9lucider i) les m\u00e9canismes mol\u00e9culaires et les fonctions biologiques du transport intracellulaire des ARNm, ii) comment les alt\u00e9rations de ces processus peuvent engendrer des maladies, et iii) comment ces connaissances peuvent servir \u00e0 l\u2019\u00e9laboration de nouvelles approches th\u00e9rapeutiques \u00e0 base d\u2019ARN. Pour comprendre ces processus, nous employons une vari\u00e9t\u00e9 d\u2019approches exp\u00e9rimentales, incluant la biologie mol\u00e9culaire et cellulaire, la biochimie, la bioinformatique, la g\u00e9n\u00e9tique de la drosophile<\/em> et des strat\u00e9gies de g\u00e9nomique fonctionnelle impliquant la microscopie \u00e0 haut-d\u00e9bit et la transcriptomique intracellulaire.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Genomics<\/li>\n
    • Bioinformatics<\/li>\n
    • Model Systems in Molecular Biology<\/li>\n
    • Systems Biology<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      The intracellular transport of mRNAs, combined with their localized translation, represents an exquisite mechanism to control the distribution of protein modules in the cell. This mechanism plays an important role in a variety of biological processes, including the specification of embryonic axes during development, cell migration and adhesion, and asymmetric cell division. Recent genomic studies suggest that mRNA localization represents a highly prevalent process, which could play a major role in cellular organization. Our laboratory is interested in elucidating i) the molecular mechanisms and biological functions of intracellular RNA transport, ii) how alterations of these processes can lead to disease, and iii) how this knowledge can be used to develop new RNA-based therapeutic approaches. To understand these processes, we employ a variety of experimental approaches, including molecular and cellular biology, biochemistry, bioinformatics, Drosophila<\/em> genetics and functional genomics strategies involving high-throughput microscopy and intracellular transcriptomics.<\/p>\n<\/div>\n\n

      Publications<\/h3>\n
        \n
      • Benoit Bouvrette, L.P., Wang, X., Boulais, J., Kong, J., Syed, E.U., Blue, S., Zhan, L., Olson, S., Stanton, R., Wei, X., Yee, B., Van Nostrand, E.L., Fu, X.-D., Burge, C.B., Graveley, B.R., Yeo, G.W., L\u00e9cuyer, E. (2022) RBP Image Database: A resource for the systematic characterization of the subcellular distribution properties of human RNA binding proteins. Nucleic Acids Research<\/em><\/strong> (In press).<\/li>\n
      • Benoit Bouvrette, L.P., Bovaird, S., Blanchette, M., and L\u00e9cuyer, E. (2020). oRNAment: A database of putative RNA binding protein target sites in transcriptomes of model species. Nucleic Acids Research<\/em><\/strong>,<\/em> 48: D166-D173.<\/li>\n
      • Bergalet, J., Patel, D., Legendre, F., Lapointe, C., Benoit Bouvrette, L.P., Chin, A., Blanchette, M., Kwon, E, and L\u00e9cuyer, E. (2020). Inter-dependent centrosomal co-localization of cen and ik2 cis-natural antisense mRNAs in Drosophila. Cell Reports<\/em><\/strong>,<\/em> 30: 3339-3352.<\/li>\n
      • Van Nostrand, E.L.*, Freese, P.*, Pratt, G.A.*, Wang, X.*, Wei, X.*, Xiao, R.*, Blue, S.M., Dominguez, D., Cody, N.A.L., Olson, S., Sundararaman, B., Zhan, L., Bazile, C., Bouvrette, L.P.B., Chen, J., Duff, M.O., Garci, K.E., Gelboin-Burkhart, C., Hochman, A., Lambert, N.J., Li, H., Ngueyn, T.B., Palden, T., Rabano, I., Sathe, S., Stanton, R., Bergalet, J., Zhou, B., Su, A., Wang, R., Yee, B.A., Louie, A. L., Aigner, S., Fu, X.-D.\u00b6<\/sup>, L\u00e9cuyer, E. \u00b6<\/sup>, Burge, C.B\u00b6<\/sup>., Graveley, B.R. \u00b6<\/sup>, Yeo, G.W. \u00b6<\/sup> 2020. A large-scale binding and functional map of human RNA binding proteins. Nature<\/em><\/strong>,<\/em> 583: 711-719. *-co-first authors, \u00b6<\/sup>= co-corresponding authors.<\/li>\n
      • Markmiller, S., Soltanieh, S., Server, K.L., Mak, R., Jin, W., Fang, M.Y., Lui, E.-C., Krach, F., Yang, D., Sen, A., Gao, F.-B., Kandel, M.W., Bennett, E.J., L\u00e9cuyer, E. and Yeo, G.W. 2018. Context-dependent and disease-specific diversity in stress granules formed form pre-existing protein interactions. Cell<\/em><\/strong>, 172: 590-604.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        Coordonn\u00e9es IRCM 514 987-5646 eric.lecuyer@ircm.qc.ca Sites web du labo\u00a0: https:\/\/www.ircm.qc.ca\/en\/researchers\/eric-lecuyer (site IRCM) https:\/\/www.lecuyerlab.org\/ (personnel) Publications Benoit Bouvrette, L.P., Wang, X., Boulais, J., Kong, J., Syed, E.U., Blue, S., Zhan, L., […]<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5598","page","type-page","status-publish","hentry"],"yoast_head":"\nL\u00e9cuyer, \u00c9ric, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/lecuyer-eric-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u00e9cuyer, \u00c9ric, Ph.D. - 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