{"id":5562,"date":"2022-08-19T13:55:40","date_gmt":"2022-08-19T17:55:40","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/les-professeurs\/trinh-vincent-quoc-huy\/"},"modified":"2022-08-19T13:55:40","modified_gmt":"2022-08-19T17:55:40","slug":"trinh-vincent-quoc-huy","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/trinh-vincent-quoc-huy\/","title":{"rendered":"Trinh, Vincent Quoc-Huy"},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Institut de recherche en immunologie et canc\u00e9rologie – IRIC
\nPavillon Marcelle-Coutu, 2306-1
\nUniversit\u00e9 de Montr\u00e9al
\nT<\/strong> 514 343-6111, p. 7894<\/p>\n

quoc-huy.trinh@umontreal.ca\u00a0<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Canc\u00e9rologie<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n
  • Biologie des syst\u00e8mes<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Notre programme de recherche porte sur le r\u00f4le des fibroblastes durant la croissance tumoral pr\u00e9-invasive dans le but d\u2019identifier de nouvelles voies de signalisation pour pr\u00e9venir la transition vers le cancer invasif du pancr\u00e9as et du foie. Nous \u00e9tudions des mod\u00e8les animaux, des mod\u00e8les cellulaires, les v\u00e9sicules extracellulaires et nanoparticules rel\u00e2ch\u00e9es par les fibroblastes en utilisant des techniques novatrices d\u2019imagerie et de pathologie. Les trois axes de recherches principaux sont\u00a0: 1) L\u2019analyse de la distribution spatiale et des param\u00e8tres m\u00e9triques de distance de sous-populations de fibroblastes, de lign\u00e9es de cellules tumorales et de classes de cellules immunes; 2) L\u2019\u00e9tude de l\u2019effet de la d\u00e9pl\u00e9tion des fibroblastes dans des mod\u00e8les murins en utilisant une nouvelle m\u00e9thode de transfert de cellules T adoptives; 3) L\u2019\u00e9tude de l\u2019effet des v\u00e9sicules extracellulaires et des nanoparticules rel\u00e2ch\u00e9s par les fibroblastes sur la fonction et la croissance des cellules tumorales.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Cancer Research<\/li>\n
    • Model systems in Molecular Biology<\/li>\n
    • Systems Biology<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      Our laboratory investigates the role of fibroblasts in premalignant tumor growth with the goal of identifying novel signaling pathways for the prevention of pancreatic and hepatic cancers. We study animal models, cellular models, extracellular vesicles, and nanoparticle release with our expertise in imaging and pathology. The three main axes of research are: 1) Analyzing the spatial distribution and distance metrics of fibroblast sub-populations, cancer cell lineages, and immune cell classes; 2) Studying the effect of fibroblast depletion in mouse models using a novel adoptive T-cell transfer depletion method; 3) Studying the effect of extracellular vesicles and nanoparticles released by precancer-associated fibroblasts on tumor cell function and growth.<\/p>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"

      Coordonn\u00e9es Institut de recherche en immunologie et canc\u00e9rologie – IRIC Pavillon Marcelle-Coutu, 2306-1 Universit\u00e9 de Montr\u00e9al T 514 343-6111, p. 7894 quoc-huy.trinh@umontreal.ca\u00a0<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5562","page","type-page","status-publish","hentry"],"yoast_head":"\nTrinh, Vincent Quoc-Huy - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/trinh-vincent-quoc-huy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trinh, Vincent Quoc-Huy - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Institut de recherche en immunologie et canc\u00e9rologie – IRIC Pavillon Marcelle-Coutu, 2306-1 Universit\u00e9 de Montr\u00e9al T 514 343-6111, p. 7894 quoc-huy.trinh@umontreal.ca\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/trinh-vincent-quoc-huy\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/trinh-vincent-quoc-huy\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/trinh-vincent-quoc-huy\/\",\"name\":\"Trinh, Vincent Quoc-Huy - 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