{"id":5547,"date":"2022-08-09T11:46:00","date_gmt":"2022-08-09T15:46:00","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/les-professeurs\/rutter-guy\/"},"modified":"2026-02-01T16:33:56","modified_gmt":"2026-02-01T21:33:56","slug":"rutter-guy","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/rutter-guy\/","title":{"rendered":"Rutter, Guy"},"content":{"rendered":"<h3>Coordonn\u00e9es<\/h3>\n<p>Centre de recherche &#8211; CHUM<br \/>\n514 890-8000, poste 27081<br \/>\n<a href=\"mailto:guy.rutter@umontreal.ca\" title=\"mailto:guy.rutter@umontreal.ca\">guy.rutter@umontreal.ca<\/a><\/p>\n<hr\/>\n<h2>Axes de recherche<\/h2>\n<ul>\n<li><span lang=\"EN-GB\">Signalisation intracellulaire<\/span><\/li>\n<li><span lang=\"EN-GB\">G\u00e9nomique<br \/>\n<\/span><\/li>\n<li><span lang=\"EN-GB\">Endocrinologie<br \/>\n<\/span><\/li>\n<li><span lang=\"EN-GB\">Bioinformatique<\/span><\/li>\n<\/ul>\n<h2>Description de la recherche<\/h2>\n<p>Mes recherches portent sur le diab\u00e8te sucr\u00e9, une maladie qui touche actuellement pr\u00e8s de 10 % de la population adulte dans le monde et dont l&#8217;incidence devrait encore augmenter dans les ann\u00e9es \u00e0 venir. Mes principaux objectifs sont de d\u00e9velopper de nouveaux moyens d&#8217;am\u00e9liorer la s\u00e9cr\u00e9tion d&#8217;insuline dans le diab\u00e8te de type 2 en \u00e9tudiant les voies de signalisation fondamentales par lesquelles le glucose, les incr\u00e9tines et d&#8217;autres hormones agissent sur la cellule \u03b2 pancr\u00e9atique et le syst\u00e8me nerveux central. Nous d\u00e9ployons les connaissances issues d&#8217;\u00e9tudes g\u00e9n\u00e9tiques et \u00e9pid\u00e9miologiques \u00e0 l&#8217;\u00e9chelle du g\u00e9nome et d&#8217;autres \u00e9tudes g\u00e9n\u00e9tiques et \u00e9pid\u00e9miologiques pour cette maladie, ainsi que des technologies de pointe telles que des mod\u00e8les de souris, l&#8217;\u00e9dition du g\u00e9nome, l&#8217;\u00e9lectrophysiologie, l&#8217;imagerie \u00e0 super-r\u00e9solution, l&#8217;optog\u00e9n\u00e9tique, la transcriptomique et la prot\u00e9omique.<\/p>\n<p>Les projets en cours comprennent :<\/p>\n<ol>\n<li>Le r\u00f4le des sous-populations de cellules b\u00eata dans le contr\u00f4le de la s\u00e9cr\u00e9tion d&#8217;insuline;<\/li>\n<li>Les m\u00e9canismes d&#8217;action des g\u00e8nes identifi\u00e9s par les \u00e9tudes d&#8217;association g\u00e9nomique a l\u2019\u00e9chelle du g\u00e9nome sur la s\u00e9cr\u00e9tion d&#8217;insuline;<\/li>\n<li>Le r\u00f4le et contr\u00f4le des g\u00e8nes \u00ab interdits \u00bb des cellules b\u00eata;<\/li>\n<li>L\u2019action des biomarqueurs circulants impliqu\u00e9s dans la progression du diab\u00e8te de type 2;<\/li>\n<li>Le contr\u00f4le de la dynamique mitochondriale par les incr\u00e9tines.<\/li>\n<\/ol>\n<hr\/>\n<h3>Publications<\/h3>\n<ul>\n<li>\n<div class=\"elementToProof\"><span lang=\"EN-GB\">Salem, V., Delgadillo Silva, L-F., Suba, K., Georgiadou, E., Mousavy, N., Akhtar, N., Martin-Alonso, A., Gaboriau, D.C.A., Rotheray, S., Stylianides, T., Carrat, G.C., Pullen, T.J., Pal Singh, S., Hodson, D.J., Leclerc, I., Shapiro, A.M. James, Marchetti, P., Briant, L.J.B., Distaso, W., Ninov, N. and <b>Rutter, G.A.<\/b> Leader beta cells coordinate Ca<sup>2+<\/sup> dynamics across pancreatic islets in vivo. Nature Metabolism 1, 625-629 (2019)<br \/>\n<\/span><\/div>\n<div class=\"elementToProof\"><span lang=\"EN-GB\"><span lang=\"EN-CA\"><\/span><\/span><\/div>\n<\/li>\n<li>\n<div class=\"elementToProof\"><span lang=\"EN-GB\"><span lang=\"EN-CA\">Akalestou, E., Suba, K., Lopez-Noriega, L., Georgiadou, E., Chabosseau, P., Gallie, A., Wretland, A., Quigley, C., <\/span>Leclerc, I., Salem, V. and <b>Rutter, G.A.<\/b> <span lang=\"EN-CA\">Intravital imaging of islet Ca<sup>2+<\/sup> dynamics reveals enhanced <\/span>\u03b2<span lang=\"EN-CA\"> cell connectivity after bariatric surgery in mice. <\/span>Nat Comms, <span class=\"docsum-journal-citation\">2(1):5165. doi: 10.1038\/s41467-021-25423-8<\/span> (2021)<br \/>\n<\/span><\/div>\n<div class=\"elementToProof\"><span lang=\"EN-GB\"><\/span><\/div>\n<\/li>\n<li>\n<div class=\"elementToProof\"><span lang=\"EN-GB\">Hu, M., Cebola, I., Carrat, G., Jiang, S., Nawaz, S., Khamnis, A., Canouil, M., Froguel, P., Schulte, A., Solimena, M., Ibberson, M., Marchetti, P., Cardenas-Diaz, F.L., Gadue, P.J., Hastoy, B., Almeida-Souza, L., McMahon, H., <b>Rutter, G.A.<\/b> Chromatin 3D interation analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion. Cell Reports <span lang=\"EN-CA\">34(5):108703. doi: 10.1016\/j.celrep.2021.108703.<\/span> PMC\u00a0 7856552 (2021)<br \/>\n<\/span><\/div>\n<div class=\"elementToProof\"><span lang=\"EN-GB\"><span lang=\"EN-CA\"><\/span><\/span><\/div>\n<\/li>\n<li>\n<div class=\"elementToProof\"><span lang=\"EN-GB\"><span lang=\"EN-CA\">Georgiadou, E., Muralidharan, C, Martinez, M., Chabosseau, P., Tomas, A., Yong Su Wern, G., Stylianides, T., Wretland, A., Leguido-Quigley, C., Alsabeeh, N., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Ali, Y., Linnemann, A.K. Rodriguez, T.A., and <b>Rutter, G.A<\/b>. Mitofusins Mfn1 and Mfn2 are required in the \u03b2-cell to preserve glucose but not incretin induced beta cell connectivity and insulin secretion,. <i>Diabetes <\/i>in press\u00a0 (2022) doi: 10.2337\/db21-0800. Online ahead of print.\u00a0<\/span><\/span><\/div>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Coordonn\u00e9es Centre de recherche &#8211; CHUM 514 890-8000, poste 27081 guy.rutter@umontreal.ca Axes de recherche Signalisation intracellulaire G\u00e9nomique Endocrinologie Bioinformatique Description de la recherche Mes recherches portent sur le diab\u00e8te sucr\u00e9, [&hellip;]<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5547","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Rutter, Guy - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/rutter-guy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rutter, Guy - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Centre de recherche &#8211; 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