{"id":5213,"date":"2020-05-21T10:21:24","date_gmt":"2020-05-21T14:21:24","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/les-professeurs\/busque-lambert-m-d\/"},"modified":"2020-05-21T11:34:13","modified_gmt":"2020-05-21T15:34:13","slug":"busque-lambert-m-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/busque-lambert-m-d\/","title":{"rendered":"Busque, Lambert, M.D."},"content":{"rendered":"<h3>Coordonn\u00e9es<\/h3>\n<p class=\"Standa1\" style=\"text-align: justify;margin: 0cm 0cm 6.0pt 4.5pt\"><span style=\"font-size: 11.0pt;font-family: 'Arial',sans-serif\" lang=\"DE\">Centre de recherche, H\u00f4pital Maisonneuve-Rosemont<br \/>\n<\/span><span style=\"font-size: 11.0pt;font-family: 'Arial',sans-serif\" lang=\"DE\">5415, boulevard de l\u2019assomption<br \/>\n<\/span><span style=\"font-size: 11.0pt;font-family: 'Arial',sans-serif\" lang=\"DE\">Montr\u00e9al (Qu\u00e9bec) H1T 2M4<br \/>\n<\/span><span style=\"font-size: 11.0pt;font-family: 'Arial',sans-serif\" lang=\"DE\"><strong>T<\/strong> 514-252-3400 #4674<\/span><\/p>\n<p class=\"Standa1\" style=\"text-align: justify;margin: 0cm 0cm 6.0pt 4.5pt\"><span lang=\"DE\"><a href=\"mailto:Lbusque.hmr@ssss.gouv.qc.ca\"><span style=\"font-size: 11.0pt;font-family: 'Arial',sans-serif\">Lbusque.hmr@ssss.gouv.qc.ca<\/span><\/a><\/span><span style=\"font-size: 11.0pt;font-family: 'Arial',sans-serif\" lang=\"DE\"><\/span><\/p>\n<hr\/>\n<div class=\"one-half first \">\n<h2>Axes de recherche<\/h2>\n<ul>\n<li>Immunologie et h\u00e9matopo\u00ef\u00e8se<\/li>\n<li>Canc\u00e9rologie<\/li>\n<\/ul>\n<h2>Description de la recherche<\/h2>\n<p>L\u2019h\u00e9matopo\u00ef\u00e8se clonale (HC) survient chez une proportion significative de la population vieillissante et est associ\u00e9e \u00e0 un risque accru de cancers h\u00e9matologiques et de maladie cardiaques. Nous avons d\u00e9crit ce ph\u00e9nom\u00e8ne en 1996 (<em>Blood<\/em>) par des techniques bas\u00e9es sur l\u2019inactivation du chromosome X.\u00a0 Nous avons d\u00e9termin\u00e9 que l\u2019HC \u00e9tait en partie caus\u00e9e par l\u2019acquisition de mutation somatique dans le g\u00e8ne<em> TET2<\/em> (<em>Nature Genet<\/em>, 2012) et caract\u00e9ris\u00e9 sa pr\u00e9valence et son impact sur la production sanguine en 2017 (<em>Blood<\/em>). Pr\u00e9sentement nous \u00e9tudions le r\u00f4le de l\u2019inflammation (<em>Nature<\/em> 2018, <em>Blood Advances,<\/em> 2020) sur l\u2019initiation de l\u2019HC et la progression clonale. Nous sommes \u00e0 d\u00e9terminer s\u2019il y a des pr\u00e9dispositions g\u00e9n\u00e9tiques \u00e0 l\u2019HC par une approche de linkage g\u00e9n\u00e9tique dans une cohorte de 230 familles.<\/p>\n<\/div>\n<div class=\"one-half  \">\n<h2>Research axis<\/h2>\n<ul>\n<li>Immunology and hematopoiesis<\/li>\n<li>Cancer<\/li>\n<\/ul>\n<h2>Research description<\/h2>\n<p>Clonal hematopoiesis (CH), which occurs in a large segment of the aging population has been clearly associated with predisposition to hematological cancer and cardiovascular disease. We first described CH 22 years ago, studying normal aging females using X-chromosome inactivation (XCI) skewing as a surrogate for clonality assessment (<em>Blood<\/em> 1996). We subsequently demonstrated that CH is partly caused by acquired somatic mutations in the <em>TET2<\/em> gene (<em>Nature Genet<\/em> 2012). We further characterized CH using a gene-targeted approach in a large cohort of 2530 normal individuals. (<em>Blood<\/em> 2017). We are currently investigating the causal factors of CH by looking at inflammation biomarkers in large cohort (<em>Nature<\/em> 2018, <em>Blood Advances<\/em> 2020) and at its genetic predisposition by genetic linkage approaches.<\/p>\n<\/div>\n<hr\/>\n<h3>Publications<\/h3>\n<ul>\n<li><u>Busque L<\/u>, Patel JP, Figueroa M, Vasanthakumar A, Provost S, Hamilou Z, Mollica L, Li J, Viale A, Heguy A, Hassim M<sup>9<\/sup>, Socci N, Gonen M, Mason CE, Melnick A, Godley LA, Brennan C, Abdel-Wahab O, Levine RL. <sup><\/sup>Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis<strong>. Nat Genet<\/strong>. 2012 Nov 1;44(11):1179-81.\u00a0 doi: 10.1038\/ng.2413. Epub 2012 Sep 23. PMID : 23001125.<\/li>\n<li>Buscarlet M, Provost<sup> <\/sup>S, Feroz Zada Y, Barhdadi A, Bourgoin V, Mollica L, Szuber<sup> <\/sup>N, Dub\u00e9<sup> <\/sup>MP, <u>Busque<sup> <\/sup>L<\/u><strong>.<\/strong> <em>DNMT3A<\/em> and <em>TET2<\/em> dominate age-associated clonal hematopoiesis, have benign hematological phenotypes but different genetic predisposition. <strong>Blood<\/strong> (2017) 130 (6), 753-762.<\/li>\n<li>Buscarlet M, Provost S, Feroz Zada Y, Vincent Bourgoin, Mollica L, Dub\u00e9 MP,<sup> <\/sup>and <u>Busque L<\/u>. Lineage restriction analyses in subjects with CHIP indicates a strong myeloid proliferation bias for TET2 and a multipotent stem cell origin for DNMT3A.<strong><\/strong> 2018 Jul 19;132(3):277-280 doi: 10.1182\/blood-2018-01-829937. Epub 2018 May 15. PMID:29764839<\/li>\n<li>Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR,\u00a0<u>Busque L<\/u>, Godley LA, Verd\u00fa EF, Barreiro LB, Jabri B. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29769727\">Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.<\/a> <strong>Nature<\/strong>. 2018 May;557(7706):580-584. doi: 10.1038\/s41586-018-0125-z. Epub 2018 May 16. PMID:29769727<\/li>\n<li>Ayachi S, Buscarlet M, <u>Busque L<\/u>. 60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations. <strong>Exp Hematol.<\/strong> 2020 Jan 28. pii: S0301-472X(20)30029-1. doi: 10.1016\/ j.exphem. 2020.01.008. [Epub ahead of print] Review. PMID: 32001340<\/li>\n<li><u>Lambert Busque<\/u>, Maxine\u00a0 Sun, Manuel Buscarlet, Sami Ayachi,Yassamin Feroz Zada, Sylvie Provost,Vincent Bourgoin, Luigina Mollica, Marlies Meisel, Reinhard Hinterleitner, Bana Jabri, \u00a0Marie-Pierre Dub\u00e9<sup> <\/sup>and Jean-Claude Tardif. High-sensitivity C-Reactive Protein is associated with Clonal Hematopoiesis of Indeterminate Potential. <strong>Blood Advances (2020)<\/strong>, in press.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Coordonn\u00e9es Centre de recherche, H\u00f4pital Maisonneuve-Rosemont 5415, boulevard de l\u2019assomption Montr\u00e9al (Qu\u00e9bec) H1T 2M4 T 514-252-3400 #4674 Lbusque.hmr@ssss.gouv.qc.ca Publications Busque L, Patel JP, Figueroa M, Vasanthakumar A, Provost S, Hamilou [&hellip;]<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5213","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Busque, Lambert, M.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/busque-lambert-m-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Busque, Lambert, M.D. - 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