{"id":4864,"date":"2018-08-24T15:52:04","date_gmt":"2018-08-24T19:52:04","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/les-professeurs\/malleshaiah-mohan-ph-d\/"},"modified":"2026-02-01T14:55:58","modified_gmt":"2026-02-01T19:55:58","slug":"malleshaiah-mohan-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/malleshaiah-mohan-ph-d\/","title":{"rendered":"Malleshaiah, Mohan, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Stem Cells and Cell Reprogramming Research Unit
\nInstitut de recherche clinique de Montr\u00e9al (IRCM)
\n110 Pine Avenue West, Montreal, QC H2W 1R7
\nT<\/strong> 514 987 5733
\nmohan.malleshaiah@ircm.qc.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Biologie des syst\u00e8mes<\/li>\n
  • Cellules souches<\/li>\n
  • Signalisation intracellulaire<\/li>\n
  • G\u00e9nomique<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Les \u00e9tats cellulaires et leurs transitions sont fondamentaux pour le d\u00e9veloppement, les maladies telles que le cancer, et la reprogrammation cellulaire. Les r\u00e9seaux r\u00e9gulateurs critiques, en particulier les prot\u00e9ines, qui traitent l’information du signal et contr\u00f4lent les \u00e9tats cellulaires et leurs transitions sont les moins bien compris.<\/p>\n

    L’unit\u00e9 de recherche en cellules souches et reprogrammation cellulaire\u00a0se concentre sur l’identification des r\u00e9gulateurs sp\u00e9cifiques \u00e0 l’\u00e9tat cellulaire, l’\u00e9lucidation de leurs r\u00e9seaux et la caract\u00e9risation de leur dynamique. Les syst\u00e8mes bas\u00e9s sur les cellules souches et les cellules canc\u00e9reuses nous fournissent des mod\u00e8les appropri\u00e9s pour \u00e9tudier les \u00e9tats cellulaires au niveau de la cellule unique. Pour comprendre les m\u00e9canismes de r\u00e9gulation des \u00e9tats cellulaires, l’\u00e9quipe combine\u00a0des mesures quantitatives d’une seule cellule (y compris la prot\u00e9omique et la g\u00e9nomique) avec des approches d’analyse computationnelle et de mod\u00e9lisation. Elle utilise\u00a0en outre la connaissance des m\u00e9canismes de r\u00e9gulation pour pr\u00e9dire et inverser les \u00e9tats cellulaires \u00e0 des fins utiles par le biais de la reprogrammation cellulaire et des strat\u00e9gies de conception mol\u00e9culaire.<\/p>\n

    Le laboratoire souhaite\u00a0acqu\u00e9rir une compr\u00e9hension holistique des m\u00e9canismes que les cellules ont \u00e9volu\u00e9 pour atteindre et maintenir des \u00e9tats cellulaires sp\u00e9cifiques. Il est \u00e9galement esp\u00e9r\u00e9 que les\u00a0conclusions transcendent les fronti\u00e8res de la discipline et r\u00e9v\u00e8lent les principes g\u00e9n\u00e9raux de conception \u00e9volu\u00e9s dans les cellules de mammif\u00e8res pour le traitement de l’information.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Systems Biology<\/li>\n
    • Stem Cells<\/li>\n
    • Intracellular Signaling<\/li>\n
    • Genomics<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      Cell states and their transitions are fundamental to development, diseases such as cancer, and cell reprogramming. The critical regulatory networks, particularly involving proteins, which process the signal information and control the cell states and their transitions are least understood.<\/p>\n

      Our research focus is to identify cell state specific regulators, elucidate their networks and characterize their dynamics. Stem cell and cancer cell-based systems provide us suitable models to study the cell states at single-cell level. To understand the regulatory mechanisms of cell states we combine quantitative single-cell measurements (including proteomics and genomics) with computational analysis and modelling approaches. We further utilize the gained knowledge of regulatory mechanisms to predict and reverse-engineer cell states for useful purposes through cell reprogramming and molecular design strategies.<\/p>\n

      Ultimately, we hope to gain holistic understanding of the mechanisms cells have evolved to achieve and maintain specific cell states. We also expect that the findings will transcend discipline boundaries and reveal general design principles evolved in mammalian cells for information processing.<\/p>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"

      Coordonn\u00e9es Stem Cells and Cell Reprogramming Research Unit Institut de recherche clinique de Montr\u00e9al (IRCM) 110 Pine Avenue West, Montreal, QC H2W 1R7 T 514 987 5733 mohan.malleshaiah@ircm.qc.ca<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4864","page","type-page","status-publish","hentry"],"yoast_head":"\nMalleshaiah, Mohan, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/malleshaiah-mohan-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Malleshaiah, Mohan, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Stem Cells and Cell Reprogramming Research Unit Institut de recherche clinique de Montr\u00e9al (IRCM) 110 Pine Avenue West, Montreal, QC H2W 1R7 T 514 987 5733 mohan.malleshaiah@ircm.qc.ca\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/malleshaiah-mohan-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-01T19:55:58+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/malleshaiah-mohan-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/malleshaiah-mohan-ph-d\/\",\"name\":\"Malleshaiah, Mohan, Ph.D. - 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