{"id":4757,"date":"2018-03-21T14:57:16","date_gmt":"2018-03-21T18:57:16","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/les-professeurs\/sauvageau-martin-ph-d\/"},"modified":"2018-03-21T15:02:42","modified_gmt":"2018-03-21T19:02:42","slug":"sauvageau-martin-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/sauvageau-martin-ph-d\/","title":{"rendered":"Sauvageau, Martin, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Laboratoire de G\u00e9nomique Fonctionnelle et ARN Non Codants Institut de Recherches Cliniques de Montr\u00e9al (IRCM)
\n110 Avenue des Pins Ouest, local 2690
\nMontr\u00e9al, QC, H2W 1R7
\nT<\/strong> 514-987-5599<\/p>\n

martin.sauvageau@ircm.qc.ca\u00a0<\/a><\/p>\n

site web externe: sauvageaulab.com<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Biologie des syst\u00e8mes<\/li>\n
  • Canc\u00e9rologie<\/li>\n
  • G\u00e9nomique<\/li>\n
  • G\u00e9n\u00e9tique Humaine et Maladies G\u00e9n\u00e9tiques<\/li>\n
  • Syst\u00e8mes Mod\u00e8les en Biologie Mol\u00e9culaire<\/li>\n
  • Bioinformatique<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    La grande majorit\u00e9 des r\u00e9gions non codantes du g\u00e9nome sont transcrites, g\u00e9n\u00e9rant de longs ARN qui ne codent pas pour les prot\u00e9ines (lncRNAs). Ces lncRNAs sont exprim\u00e9s avec une tr\u00e8s grande sp\u00e9cificit\u00e9 tissulaire et plusieurs preuves indiquent qu\u2019ils sont fonctionnellement importants, jouant un r\u00f4le r\u00e9gulateur n\u00e9cessaire au bon fonctionnement de nos cellules. Les lncRNAs sont \u00e9galement fr\u00e9quemment d\u00e9r\u00e9gl\u00e9s ou mut\u00e9s dans une grande vari\u00e9t\u00e9 de maladies humaines. Mais, leur contribution au d\u00e9veloppement et \u00e0 la progression des maladies et leur mode d’action mol\u00e9culaire restent largement inconnus. Ainsi, l\u2019un des principaux d\u00e9fis pour comprendre l\u2019influence de ces mol\u00e9cules non codantes sur la sant\u00e9 humaine est non seulement de d\u00e9terminer lesquelles sont fonctionnelles, mais aussi de d\u00e9chiffrer la fa\u00e7on dont elles accomplissent leurs t\u00e2ches et contribuent au d\u00e9veloppement de maladies.<\/p>\n

    Notre laboratoire tire parti des donn\u00e9es g\u00e9n\u00e9tiques humaines pour identifier les lncRNAs dans les r\u00e9gions g\u00e9nomiques \u00e0 risque. Nous combinons des mod\u00e8les murins g\u00e9n\u00e9tiquement modifi\u00e9s et des mod\u00e8les cellulaires humains avec la g\u00e9nomique fonctionnelle et des techniques d\u2019\u00e9dition de g\u00e9nome bas\u00e9es sur CRISPR pour perturber les fonctions des lncRNAs et caract\u00e9riser leur r\u00f4le. Nous cherchons \u00e9galement \u00e0 d\u00e9couvrir de nouveaux m\u00e9canismes non codants bas\u00e9s sur l’ARN en caract\u00e9risant les interactions mol\u00e9culaires et les principes de r\u00e9gulation qui sous-tendent la fonction des lncRNAs. Pour cela, nous utilisons une combinaison de biochimie, d\u2019\u00e9dition du g\u00e9nome, de genomique fonctionnelle et de bioinformatique pour identifier les prot\u00e9ines interagissantes et comprendre comment des s\u00e9quences sp\u00e9cifiques m\u00e9dient la fonction des lncRNAs . Notre objectif est de mieux comprendre l\u2019impact des lncRNAs et des r\u00e9gions non codantes sur la sant\u00e9 et les maladies et de fournir les bases g\u00e9n\u00e9tiques et mol\u00e9culaires pour le d\u00e9veloppement de nouveaux diagnostics et de traitements ciblant l’ARN.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Systems Biology<\/li>\n
    • Cancer<\/li>\n
    • Genomics<\/li>\n
    • Human Genetics and Genetic Diseases<\/li>\n
    • Model Systems in Molecular Biology<\/li>\n
    • Bioinformatics<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      Our understanding of how the genome is regulated has changed by discovering that the vast majority of noncoding regions in the genome are transcribed, generating long RNAs that don’t encode proteins (lncRNAs). Thousands of lncRNA genes, expressed with exquisite tissue specificity, have been identified and several evidence indicate that they are functionally important and perform regulatory roles necessary for the proper functioning of our cells. lncRNAs are also frequently misregulated or mutated in a wide variety of human diseases. But, their contribution to the development and progression of diseases and their molecular mode of action remain largely unknown. Thus, one of the main challenge to understand the noncoding genome\u2019s influence on human health is not only to determine which lncRNAs are functional, but also to decipher how they perform their tasks and affect the pathophysiology of diseases.<\/p>\n

      Our laboratory takes advantage of human genetics data to identify lncRNAs in disease risk genomic regions. We combine genetically engineered mouse models and human cell systems with functional genomics and CRISPR-based genome editing techniques to perturb lncRNA functions and characterize their role. We also aim to uncover novel noncoding RNA-based mechanisms by characterizing the molecular interactions and regulatory principles underlying the function of lncRNAs. For this, we use a combination of biochemistry, genome editing, computational and high-throughput genomics approaches to identify interacting proteins and understand how specific domains or RNA sequences within lncRNAs mediate their function. Our goal is to better understand the impact that lncRNAs and noncoding regions have on human health and diseases and provide the necessary genetics and molecular bases towards the development of novel diagnostics and RNA-targeting therapeutics.<\/p>\n<\/div>\n\n

      Publications<\/h3>\n
        \n
      • Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D Vora S, Victor J, Sauvageau M, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. An Integrated Genome Wide CRISPRa Approach to Study Drug Resistance Uncovers Coding and Noncoding Networks . Cell (In Press). (2018)<\/li>\n
      • Groff AF, Sanchez-Gomez DB, Soruco ML, Gerhardinger C, Barutcu R, Li E, Elcavage L, Plana O, Sanchez LV, Lee JC, Sauvageau M, Rinn JL. In vivo characterization of linc-p21 reveals functional cis-regulatory DNA elements. Cell Reports, 16: 2178-2186. (2016)<\/li>\n
      • *Goff LA, *Groff AF, *Sauvageau M, Trayes-Gibson Z, Sanchez-Gomez DB, Morse M, Martin R, Elcavage, LE, Liapis SC, Gonzalez-Celerio M, Plana O, Li E, Lai V, Frendewey D, Valenzuela DM, Yancopoulos GD, Gerhardinger C, Tomassy GS, Arlotta P, Rinn JL. Spatio-temporal expression and transcriptional perturbations by long noncoding RNAs in the mammalian brain. PNAS, 112: 8655-6862. (2015)<\/li>\n
      • Hacisuleyman E, Goff LA, Trapnell C, Sun L, Williams A, Henao-Mejia J, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Guttman M, Lander ES, Lodish HF, Flavell R, Raj A, Rinn JL. Topological organization of multichromosomal regions by the long noncoding RNA Firre. Nature Structural & Molecular Biology, 21: 198-206.\u00a0 (2014)<\/li>\n
      • Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D\u2019Ecclessis MF, Moore JC, Lai V, Gong, G, Yancopoulos GD, Frendewey D, Hart RP, Valenzuela DM, Arlotta P, Rinn JL. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. eLife, 2: e01749.\u00a0 (2013)<\/li>\n<\/ul>\n

         <\/p>\n","protected":false},"excerpt":{"rendered":"

        Coordonn\u00e9es Laboratoire de G\u00e9nomique Fonctionnelle et ARN Non Codants Institut de Recherches Cliniques de Montr\u00e9al (IRCM) 110 Avenue des Pins Ouest, local 2690 Montr\u00e9al, QC, H2W 1R7 T 514-987-5599 martin.sauvageau@ircm.qc.ca\u00a0 […]<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4757","page","type-page","status-publish","hentry"],"yoast_head":"\nSauvageau, Martin, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/sauvageau-martin-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sauvageau, Martin, Ph.D. - 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