Institut de recherches cliniques de Montr\u00e9al (IRCM) Notre recherche vise \u00e0 clarifier la fa\u00e7on dont les cellules souches h\u00e9matopo\u00ef\u00e9tiques sont programm\u00e9es pour maintenir leur capacit\u00e9 d’auto-renouvellement et de diff\u00e9renciation dans multiples lign\u00e9es de cellules sanguines. Nous cherchons \u00e0 comprendre comment les d\u00e9fauts de ce processus biologique peuvent provoquer un d\u00e9veloppement des cancers du sang mortelles telles que la leuc\u00e9mie et le lymphome, pour am\u00e9liorer les traitement existantes par une th\u00e9rapie plus cibl\u00e9es et plus efficace. Notre recherche se concentre en particulier sur les m\u00e9canismes mol\u00e9culaires qui contr\u00f4lent la transcription par modification \u00e9pig\u00e9n\u00e9tique de la chromatine. Nous avons choisi d’\u00e9tudier la fonction des r\u00e9gulateurs de transcription Gfi1 et Gfi1b (\u201cG<\/b>rowth f<\/b>actor i<\/b>ndependence 1<\/b> and –1b<\/b>\u201d), Miz-1 (\u201cM<\/b>yc i<\/b>nteracting z<\/b>inc finger protein 1\u201d<\/b>) et plus r\u00e9cemment hnRNP L (\u201ch<\/b>eterogen<\/b>ous R<\/b>ibon<\/b>ucleop<\/b>rotein L<\/b>\u201d). Gfi1 et Gfi1b sont mut\u00e9s dans certaines maladies humaines affectant l’h\u00e9matopo\u00ef\u00e8se comme la neutrop\u00e9nie cong\u00e9nitale s\u00e9v\u00e8re ou de troubles h\u00e9r\u00e9ditaires de la coagulation. Gfi1 et Gfi1b sont aussi impliqu\u00e9s dans le d\u00e9veloppement ou la progression des leuc\u00e9mies aigu\u00ebs de type my\u00e9lo\u00efde ou lympho\u00efde (LMA ou LLA) et Gfi1 a un r\u00f4le particulier dans le contr\u00f4le du stress oncog\u00e9nique dans les cellules leuc\u00e9miques. Miz-1 est n\u00e9cessaire aux stades pr\u00e9coces de la diff\u00e9renciation lympho\u00efde, mais est \u00e9galement un co-facteur important de l’oncoprot\u00e9ine c-Myc, qui joue un r\u00f4le dans nombreux types de leuc\u00e9mies et de lymphomes humaines. Finalement, la prot\u00e9ine hnRNP L a r\u00e9cemment, qui est aussi \u00e9tudi\u00e9e dans notre laboratoire, a \u00e9t\u00e9 reconnue comme un r\u00e9gulateur de d\u00e9veloppement pr\u00e9coce des cellules T et comme un facteur important tr\u00e8s r\u00e9cemment dans la r\u00e9ponse des cellules souches h\u00e9matopo\u00ef\u00e9tiques au stress.<\/p>\n<\/div>\n Our research aims to clarify how hematopoietic stem cells are programmed to maintain their ability for self renewal and at the same time to enable multi-lineage differentiation through the generation of lineage restricted progenitor cells. Further, we aim to understand how defects in this biological process can cause fatal blood cancers such as leukemia and lymphoma, for which improved and targeted therapies are urgently needed. Our research is focused on the molecular mechanisms that control transcription through epigenetic modification of chromatin. We have chosen to study the function of the transcriptional regulators Gfi1 and Gfi1b (\u201cG<\/b>rowth f<\/b>actor i<\/b>ndependence 1<\/b> and –1b<\/b>\u201d), Miz-1 (\u201cM<\/b>yc i<\/b>nteracting z<\/b>inc finger protein 1\u201d<\/b>) and more recently hnRNP L (\u201ch<\/b>eterogen<\/b>ous R<\/b>ibon<\/b>ucleop<\/b>rotein L<\/b>\u201d). Gfi1 and Gfi1b are mutated in certain human diseases affecting hematopoiesis such as severe congenital neutropenia or inherited bleeding disorders. Both Gfi1 and Gfi1b are implicated in the development or progression of human myeloid leukemia and Gfi1 has a particular role in antagonizing the effects of oncogenic stress in lymphoid leukemia. Miz-1 is required for early lymphoid differentiation, but is also an important co-factor of the oncoprotein c-Myc, which plays a role in many different types of human leukemia and lymphoma. The hnRNP L protein, which is also under investigation in our lab, has recently been recognized as a regulator of early T cell development and as an important factor in the response of hematopoietic stem cells to external stress.<\/p>\n<\/div>\n Coordonn\u00e9es Institut de recherches cliniques de Montr\u00e9al (IRCM) T 514 987 5776 Tarik.Moroy@ircm.qc.ca Consultez le site web du chercheur<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-4069","page","type-page","status-publish","hentry"],"yoast_head":"\n
\nT<\/strong> 514 987 5776
\nTarik.Moroy@ircm.qc.ca<\/a><\/p>\nAxes de recherche<\/h2>\n
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Description de la recherche<\/h2>\n
Research axis<\/h2>\n
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Research description<\/h2>\n
Consultez le site web du chercheur<\/a><\/h3>\n