{"id":3718,"date":"2012-07-11T10:02:05","date_gmt":"2012-07-11T14:02:05","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/wurtele-hugo-ph-d\/"},"modified":"2026-02-01T16:48:37","modified_gmt":"2026-02-01T21:48:37","slug":"wurtele-hugo-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wurtele-hugo-ph-d\/","title":{"rendered":"Wurtele, Hugo, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Centre de recherche H\u00f4pital Maisonneuve Rosemont
\n5415, boulevard de l’Assomption
\nMontr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada
\nT<\/strong> 514 252-3400 #7288
\nT<\/strong> (labo) 514 252-3400 #4302
\nF<\/strong> 514 252-3430
\nhugo.wurtele@umontreal.ca<\/a><\/p>\n

https:\/\/crhmr.ciusss-estmtl.gouv.qc.ca\/en\/researcher\/hugo-wurtele<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Interactions prot\u00e9iques<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n
  • Canc\u00e9rologie<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Les dommages \u00e0 l’ADN peuvent conduire \u00e0 l’inactivation ou \u00e0 la d\u00e9r\u00e9gulation de g\u00e8nes et causer diverses maladies comme le cancer. Plusieurs m\u00e9canismes de r\u00e9paration de l’ADN permettent aux cellules de survivre \u00e0 ces dommages. Par contre, ces m\u00e9canismes peuvent aussi compromettre l’efficacit\u00e9 des traitements de chimioth\u00e9rapie qui tuent les cellules canc\u00e9reuses en induisant des dommages massifs \u00e0 l’ADN. La recherche sur la r\u00e9ponse cellulaire aux dommages \u00e0 l’ADN est donc cruciale pour mieux comprendre le cancer et pour le d\u00e9veloppement de nouvelles modalit\u00e9s de traitements. Pour pouvoir s’ajuster \u00e0 la taille r\u00e9duite des cellules, l’ADN est empaquet\u00e9 sous la forme d’une structure appel\u00e9e chromatine. Nous utilisons la levure comme syst\u00e8me mod\u00e8le pour comprendre comment la structure de la chromatine participe \u00e0 la r\u00e9ponse cellulaire \u00e0 des agents qui endommagent l’ADN similaires \u00e0 ceux utilis\u00e9s en clinique.<\/p>\n

    Plus sp\u00e9cifiquement, nous nous int\u00e9ressons aux modifications post-traductionnelles des histones nouvellement synth\u00e9tis\u00e9es qui sont incorpor\u00e9es dans la chromatine durant la r\u00e9plication de l’ADN. Plusieurs \u00e9vidences relient ces modifications \u00e0 la r\u00e9gulation de certaines ubiquitine ligases et \u00e0 la r\u00e9paration de l’ADN par recombinaison homologue. Nous utilisons donc des approches de microscopie par fluorescence, de biochimie et de g\u00e9n\u00e9tique pour d\u00e9terminer l’impact de la structure de la chromatine sur les m\u00e9canismes de r\u00e9paration de l’ADN coupl\u00e9s \u00e0 la r\u00e9plication.<\/p>\n

    Une meilleure compr\u00e9hension de ces ph\u00e9nom\u00e8nes pourrait conduire \u00e0 la mise au point de nouveaux traitements contre le cancer et mener \u00e0 l’identification de\u00a0 marqueurs mol\u00e9culaires pour cat\u00e9goriser les tumeurs et mieux d\u00e9finir le traitement appropri\u00e9.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Protein interaction<\/li>\n
    • Model systems in molecular biology<\/li>\n
    • Cancer<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      DNA damage can lead to the inactivation or misregulation of important genes and to diseases such as cancer. DNA repair mechanisms allow cells to survive to these lesions. On the other hand, repair processes can also compromise the efficacy of chemotherapy treatments which kill cancer cells by inducing lethal DNA damage. Investigation the cellular response to DNA damage is thus crucial for our understanding of cancer and for the development of new therapeutic strategies.<\/p>\n

      In order to fit into the tiny confines of the cell, DNA is packaged into a structure called chromatin. We are using yeast as a model system to understand how chromatin structure influences the cellular response to genotoxic drugs that are similar to those used in cancer chemotherapy. More specifically, we are interested in post-translational modifications that are specifically found in newly synthesized histones that are incorporated into chromatin during DNA replication. Many lines of evidence link these modifications to the regulation of ubiquitin ligase complexes and to homologous recombination repair of DNA replication damage. We are thus using approaches such as fluorescence microscopy, biochemistry and genetics to characterize the role of chromatin structure in the repair of DNA damage during replication.<\/p>\n

      We anticipate that a better understanding of these processes could lead to novel cancer treatments and to the identification of new molecular markers for cancer prognosis.<\/p>\n<\/div>\n\n

       <\/p>\n","protected":false},"excerpt":{"rendered":"

      Coordonn\u00e9es Centre de recherche H\u00f4pital Maisonneuve Rosemont 5415, boulevard de l’Assomption Montr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada T 514 252-3400 #7288 T (labo) 514 252-3400 #4302 F 514 252-3430 hugo.wurtele@umontreal.ca https:\/\/crhmr.ciusss-estmtl.gouv.qc.ca\/en\/researcher\/hugo-wurtele […]<\/p>\n","protected":false},"author":216,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3718","page","type-page","status-publish","hentry"],"yoast_head":"\nWurtele, Hugo, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wurtele-hugo-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wurtele, Hugo, Ph.D. - 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