Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n<\/ul>\nDescription de la recherche<\/h2>\n
La r\u00e9gulation transcriptionnelle est un processus complexe qui exige le recrutement de l\u2019ARN polym\u00e9rase vers les sites dirig\u00e9s de transcription, la modification de la structure locale de la chromatine et l\u2019\u00e9pissage des nouveaux transcrits. Une interruption de la coordination de ce processus, comme la transcription erron\u00e9e qui active de fa\u00e7on inappropri\u00e9e des g\u00e8nes qui modifient le comportement normal des cellules, peut favoriser l\u2019apparition d\u2019un cancer. Dans le but de comprendre clairement la nature de cette anomalie, il est souvent n\u00e9cessaire d\u2019avoir un aper\u00e7u global du syst\u00e8me.<\/p>\n
Notre \u00e9quipe de recherche s\u2019int\u00e9resse actuellement \u00e0 l\u2019utilisation des technologies d\u2019avant-garde, \u00e0 haut d\u00e9bit, comme les biopuces \u00e0 ADN et le s\u00e9quen\u00e7age d\u2019ADN de nouvelle g\u00e9n\u00e9ration afin d\u2019\u00e9lucider les connexions sous-jacentes \u00e0 l\u2019activit\u00e9 transcriptionnelle et au comportement des cellules. Pour comprendre ce ph\u00e9nom\u00e8ne dans le contexte de la biologie du cancer, nous utilisons actuellement ces approches pour caract\u00e9riser les \u00e9chantillons de patients atteints de la leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) dans le but d\u2019identifier les mutations qui favorisent l\u2019apparition de la maladie. De plus, nous utilisons la levure \u00e0 fission (Schizosaccharomyces pombe<\/em>) comme syst\u00e8me mod\u00e8le pour \u00e9tudier le recrutement de l\u2019ARN polym\u00e9rase II et son comportement pendant la transcription. Le fait de mieux comprendre la machinerie mol\u00e9culaire qui est \u00e0 la base de ces processus nous permettra ultimement de mettre au point de nouveaux m\u00e9dicaments pour traiter le cancer.<\/p>\n<\/div>\n\n
Research Axis<\/h2>\n\n- Genomics<\/li>\n
- Cancer<\/li>\n
- Bioinformatics<\/li>\n
- Model systems in molecular biology<\/li>\n<\/ul>\n
Research description<\/h2>\n
Transcriptional regulation is a complex process requiring the recruitment of RNA Polymerase to directed sites of transcription, modification of the local chromatin structure, and coordinated splicing and export of the novel transcript. A breakdown in the coordination of this process, such as misdirected transcription which inappropriately activates genes that alter the cells normal behaviour, can result in the development of cancer. In order to clearly understand the exact nature of the defect, it is often necessary to acquire a global view of the system.<\/p>\n
Our research team is currently interested in using cutting-edge, high-throughput technologies such as microarrays and next-generation sequencing to elucidate the connections underlying transcriptional activity and cellular behaviour. To understand this in the context of cancer biology, we are currently using these approaches to characterize primary Acute Myeloid Leukemia (AML) patient samples in order to identify mutations giving rise to the disease. Additionally, we use fission yeast (Schizosaccharomyces pombe) <\/em>as a model system to study the recruitment of RNA Polymerase II and its behaviour during transcription. Gaining a better understanding of the molecular machinery behind these processes will ultimately better enable us to develop novel drugs to treat cancer.<\/p>\n<\/div>\n\n <\/p>\n","protected":false},"excerpt":{"rendered":"
Assistant professeur D\u00e9partement de m\u00e9decine Coordonn\u00e9es 1306-11, IRIC – UdeM Pavillon Marcelle-Coutu, 2950 chemin de Polytechnique T 514-343-6111 #0923 F 514-343-7780 brian.wilhelm@umontreal.ca 2900, boulevard \u00c9douard-Montpetit Pavillon Marcelle-Coutu, Quai 20 Montreal […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3717","page","type-page","status-publish","hentry"],"yoast_head":"\n
Wilhelm, Brian, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wilhelm, Brian, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Assistant professeur D\u00e9partement de m\u00e9decine Coordonn\u00e9es 1306-11, IRIC – UdeM Pavillon Marcelle-Coutu, 2950 chemin de Polytechnique T 514-343-6111 #0923 F 514-343-7780 brian.wilhelm@umontreal.ca 2900, boulevard \u00c9douard-Montpetit Pavillon Marcelle-Coutu, Quai 20 Montreal […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-01T21:48:03+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/\",\"name\":\"Wilhelm, Brian, Ph.D. - Programmes de biologie mol\u00e9culaire\",\"isPartOf\":{\"@id\":\"https:\/\/biomol.umontreal.ca\/#website\"},\"datePublished\":\"2012-01-24T16:49:02+00:00\",\"dateModified\":\"2026-02-01T21:48:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Our professors\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Wilhelm, Brian, Ph.D.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/biomol.umontreal.ca\/#website\",\"url\":\"https:\/\/biomol.umontreal.ca\/\",\"name\":\"Programmes de biologie mol\u00e9culaire\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/biomol.umontreal.ca\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Wilhelm, Brian, Ph.D. - Programmes de biologie mol\u00e9culaire","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/","og_locale":"en_US","og_type":"article","og_title":"Wilhelm, Brian, Ph.D. - Programmes de biologie mol\u00e9culaire","og_description":"Assistant professeur D\u00e9partement de m\u00e9decine Coordonn\u00e9es 1306-11, IRIC – UdeM Pavillon Marcelle-Coutu, 2950 chemin de Polytechnique T 514-343-6111 #0923 F 514-343-7780 brian.wilhelm@umontreal.ca 2900, boulevard \u00c9douard-Montpetit Pavillon Marcelle-Coutu, Quai 20 Montreal […]","og_url":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/","og_site_name":"Programmes de biologie mol\u00e9culaire","article_modified_time":"2026-02-01T21:48:03+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/","url":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/","name":"Wilhelm, Brian, Ph.D. - Programmes de biologie mol\u00e9culaire","isPartOf":{"@id":"https:\/\/biomol.umontreal.ca\/#website"},"datePublished":"2012-01-24T16:49:02+00:00","dateModified":"2026-02-01T21:48:03+00:00","breadcrumb":{"@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/wilhelm-brian-ph-d\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/biomol.umontreal.ca\/en\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/biomol.umontreal.ca\/en\/research\/"},{"@type":"ListItem","position":3,"name":"Our professors","item":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/"},{"@type":"ListItem","position":4,"name":"Wilhelm, Brian, Ph.D."}]},{"@type":"WebSite","@id":"https:\/\/biomol.umontreal.ca\/#website","url":"https:\/\/biomol.umontreal.ca\/","name":"Programmes de biologie mol\u00e9culaire","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/biomol.umontreal.ca\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3717","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/comments?post=3717"}],"version-history":[{"count":2,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3717\/revisions"}],"predecessor-version":[{"id":6909,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3717\/revisions\/6909"}],"up":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3557"}],"wp:attachment":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/media?parent=3717"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}