{"id":3711,"date":"2012-01-24T10:44:46","date_gmt":"2012-01-24T15:44:46","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/trudel-marie-d-sc\/"},"modified":"2014-03-10T11:05:22","modified_gmt":"2014-03-10T15:05:22","slug":"trudel-marie-d-sc","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/trudel-marie-d-sc\/","title":{"rendered":"Trudel, Marie, D.Sc."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRCM
\nT<\/strong> 514 987-5712
\nF<\/strong> 514 987-5585
\nmarie.trudel@ircm.qc.ca<\/a>
\n<\/p>\n

\n

Axes de recherche<\/h2>\n
    \n
  • Approches th\u00e9rapeutiques<\/li>\n
  • D\u00e9veloppement et diff\u00e9renciation tissulaire<\/li>\n
  • G\u00e9n\u00e9tique humaine et maladies g\u00e9n\u00e9tiques<\/li>\n
  • Immunologie et h\u00e9matopo\u00ef\u00e8se<\/li>\n
  • Signalisation intracellulaire<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    \u00c9tude de g\u00e9n\u00e9tique mol\u00e9culaire sur le d\u00e9veloppement in vivo. Caract\u00e9risation des m\u00e9canismes mol\u00e9culaires r\u00e9gulant l\u2019h\u00e9matopoi\u00e8se normale et anormale e.g. la leuc\u00e9mie; plus particuli\u00e8rement, nous \u00e9tudions le r\u00f4le de certains facteurs transcriptionnels et la r\u00e9gulation des g\u00e8nes de globines en utilisant l\u2019approche des souris transg\u00e9niques et knock-out. Gr\u00e2ce \u00e0 la cr\u00e9ation de notre mod\u00e8le murin d\u2019an\u00e9mie falciforme, nous d\u00e9veloppons et \u00e9valuons de nouvelles approches de th\u00e9rapie g\u00e9nique \u00e0 partir de techniques optimis\u00e9es de transplantation de moelle osseuse, de transfert de g\u00e8nes et de nouveaux vecteurs. Analyse mol\u00e9culaire du d\u00e9veloppement et de l\u2019induction de la diff\u00e9renciation cellulaire du rein, un syst\u00e8me mod\u00e8le pour de nombreux ph\u00e9nom\u00e8nes ontog\u00e9niques. D\u00e9finir in vivo les interactions mol\u00e9culaires de certains protooncog\u00e8nes nucl\u00e9aires et du g\u00e8ne de la polykystose r\u00e9nale PKDI et leurs voies de signalisation.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Therapeutic approaches<\/li>\n
    • Development and tissue differentiation<\/li>\n
    • Immunology and Haematopoiesis<\/li>\n
    • Human genetics and genetic diseases<\/li>\n
    • Intracellular signaling<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      Study of molecular genetic in development in vivo. Characterization of the molecular mechanisms regulating normal and abnormal (e.g. leukemia) hematopoiesis; particularly, we are studying the role of certain transcription factors and globin gene regulation by using transgenic and knock-out mice approaches. Due to the creation of our mouse model of sickle cell disease, we are developing and evaluating novel approaches of gene therapy from optimized techniques of bone marrow transplantation, gene transfer and new vectors. Molecular analysis of development and induction of kidney cellular differentiation, the model system for numerous ontogenic phenomena. Define the molecular interactions of certain nuclear protooncogenes and of PKDI, the gene of polycystic disease, and their signal transduction pathways.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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