{"id":3704,"date":"2012-01-24T09:27:45","date_gmt":"2012-01-24T14:27:45","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/seidah-nabil-g-ph-d\/"},"modified":"2026-02-01T16:35:14","modified_gmt":"2026-02-01T21:35:14","slug":"seidah-nabil-g-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/seidah-nabil-g-ph-d\/","title":{"rendered":"Seidah, Nabil G., Ph.D."},"content":{"rendered":"<h3>Coordonn\u00e9es<\/h3>\n<p>IRCM<br \/>\n<strong>T<\/strong> 514 987-5609<br \/>\n<a href=\"mailto:seidahn@ircm.qc.ca\">seidahn@ircm.qc.ca<\/a><br \/>\n<hr\/><\/p>\n<div class=\"one-half first \">\n<h2>Axes de recherche<\/h2>\n<ul>\n<li>Interactions prot\u00e9iques<\/li>\n<li>Maladies cardiovasculaires<\/li>\n<li>G\u00e9n\u00e9tique humaine et maladies g\u00e9n\u00e9tiques<\/li>\n<li>Approches th\u00e9rapeutiques<\/li>\n<\/ul>\n<h2>Description de la recherche<\/h2>\n<p>Cette unit\u00e9 de recherche se consacre \u00e0 l\u2019\u00e9tude de neuf proprot\u00e9ines convertases (PCs) de mammif\u00e8res et une m\u00e9talloendopeptidase NRDc. Les s\u00e9rines prot\u00e9inases sont majoritairement responsables de l\u2019activation des pr\u00e9curseurs d\u2019hormones, des enzymes, des facteurs de croissance et de transcription, des r\u00e9cepteurs et des prot\u00e9ines d\u2019enveloppes d\u2019agents pathog\u00e8nes. Les chercheurs de cette \u00e9quipe veulent d\u00e9finir le m\u00e9canisme d\u2019action de ces enzymes et leur r\u00e9gulation, ainsi que l\u2019identification et la production d\u2019inhibiteurs, et d\u00e9terminer leurs r\u00f4les physiologiques et leurs implications cliniques. Pour ce faire, ils exploitent des techniques modernes de biochimie des prot\u00e9ines et des peptides, d\u2019enzymologie, de biologie mol\u00e9culaire et cellulaire, et des analyses impliquant des techniques de prot\u00e9omique, de purification par affinit\u00e9, de transgen\u00e8se et de recombinaison g\u00e9nique. Le r\u00f4le de PC7 dans l\u2019anxi\u00e9t\u00e9, de PCSK9 dans l\u2019hypercholest\u00e9rol\u00e9mie familiale sont deux exemples concrets de convertases qui ont des applications cliniques en maladies neurod\u00e9g\u00e9n\u00e9ratives et dans les troubles cardiovasculaires reli\u00e9s au haut taux de cholest\u00e9rol circulant.<\/p>\n<\/div>\n<div class=\"one-half  \">\n<h2>Research axis<\/h2>\n<ul>\n<li>Protein interactions<\/li>\n<li>Cardiovascular diseases<\/li>\n<li>Human genetics and genetic diseases<\/li>\n<li>Therapeutic approaches<\/li>\n<\/ul>\n<h2>Research description<\/h2>\n<p>We focus our research on a family of nine mammalian protein convertases (PCs): PC1, PC2, Furin, PC4, PC5, PACE4, PC7, SKI-1 and PCSK9. These enzymes are involved in the activation of hormone precursors, growth or transcription factors, receptors, or envelope proteins for pathogenic agents. The team uses a broad range of techniques: protein and peptide biochemistry, enzymology, molecular and cell biology, proteomics and genetics. The lab possesses a unique collection of mutants and has completed full and\/or conditional knockouts on PC5, Furin, PC7 and PCSK9. PCSK9 is a special target for attacking familial hypercholesterolemia.\u00a0 The role PC7 plays in the central nervous system appears to be connected to the development of anxiety, as mice whose PC7 (PCSK7) gene has been invalidated present with a tranquilizer phenotype. The key roles SKI-1 and PCSK9 play in cholesterol homeostasis have led the team to expand and to devote considerable efforts to developing pharmacological applications related to cardiovascular diseases.<\/p>\n<\/div>\n<hr\/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Coordonn\u00e9es IRCM T 514 987-5609 seidahn@ircm.qc.ca &nbsp;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3704","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Seidah, Nabil G., Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/seidah-nabil-g-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Seidah, Nabil G., Ph.D. - 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