{"id":3695,"date":"2012-01-23T16:39:04","date_gmt":"2012-01-23T21:39:04","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/royal-isabelle-ph-d\/"},"modified":"2013-08-16T16:12:44","modified_gmt":"2013-08-16T20:12:44","slug":"royal-isabelle-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/royal-isabelle-ph-d\/","title":{"rendered":"Royal, Isabelle, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Centre de recherche du CHUM
\nH\u00f4pital Notre-Dame
\nPavillon J.A. de S\u00e8ve, Y4605
\nT<\/strong> 514 890-8000 #25497
\nF<\/strong> 514 412-7591
\nisabelle.royal@umontreal.ca<\/a>
\n<\/p>\n

\n

Axes de recherche<\/h2>\n
    \n
  • Signalisation intracellulaire<\/li>\n
  • Canc\u00e9rologie<\/li>\n
  • Interactions prot\u00e9iques<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire.<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    La formation de nouveaux vaisseaux sanguins (angiogen\u00e8se) dans les tumeurs est essentielle \u00e0 leur croissance agressive et facilite le d\u00e9veloppement de m\u00e9tastases. Dans ce contexte, les travaux du laboratoire se concentrent sur l’identification de m\u00e9canismes mol\u00e9culaires impliqu\u00e9s dans la r\u00e9gulation de la r\u00e9ponse des cellules des vaisseaux sanguins au VEGF, un des plus puissants inducteurs de l’angiogen\u00e8se tumorale. Plus particuli\u00e8rement, nous nous int\u00e9ressons \u00e0 la d\u00e9finition des voies de signalisation qui contr\u00f4lent la survie, la perm\u00e9abilit\u00e9, la migration et l\u2019invasion des cellules de l’endoth\u00e9lium, ainsi que la formation de nouveaux vaisseaux in vitro et in vivo. Le but ultime de ces travaux est l’identification de m\u00e9canismes-cl\u00e9s qui pourraient \u00e9ventuellement permettre le d\u00e9veloppement d’outils th\u00e9rapeutiques pour contrer l’angiogen\u00e8se associ\u00e9e aux tumeurs, et par cons\u00e9quent, la progression tumorale. Les projets actuels du laboratoire se concentrent sur:<\/p>\n

      \n
    1. l\u2019\u00e9tude des \u00e9v\u00e9nements mol\u00e9culaires en aval des prot\u00e9ines d\u2019\u00e9chafaudage Gab1 et Gab2 qui sont impliqu\u00e9es dans l\u2019angiogen\u00e8se;<\/li>\n
    2. l\u2019\u00e9lucidation du r\u00f4le de la prot\u00e9ine tyrosine phosphatase DEP-1 dans la r\u00e9gulation de la r\u00e9ponse angiog\u00e9nique et la progression tumorale; et<\/li>\n
    3. l\u2019identification des modifications post-traductionnelles contr\u00f4lant la fonction de la phosphatase DEP-1 dans les cellules endoth\u00e9liales et canc\u00e9reuses.<\/li>\n<\/ol>\n<\/div>\n
      \n

      Research axis<\/h2>\n
        \n
      • intracellular signalling<\/li>\n
      • cancer<\/li>\n
      • protein interactions<\/li>\n
      • model systems in molecular biology<\/li>\n<\/ul>\n

        Research description<\/h2>\n

        The formation of new blood vessels in tumors, a process called angiogenesis, is essential for their aggressive growth and facilitates the development of metastases. In this context, research from our laboratory is focused on the identification of molecular mechanisms regulating the response of blood vessel cells (endothelial cells) to VEGF, one of the most potent inducer of tumor-associated angiogenesis. In particular, we are interested in defining VEGF-dependent signaling pathways that control the survival, permeability, migration and invasion of endothelial cells, as well as the formation of new capillaries in vitro and in vivo. The ultimate goal of our research is to identify key regulatory events that may lead to the development of new therapeutic avenues to block tumor-associated angiogenesis, and consequently, tumor progression. Our major ongoing\u00a0research projects are focused on:<\/p>\n

          \n
        1. the identification of the signaling pathways controlled by the scaffolding adapters Gab1 and Gab2 that regulate VEGF-induced angiogenesis;<\/li>\n
        2. the elucidation of the role of the protein tyrosine-phosphatase DEP-1 in the regulation of angiogenesis and tumor progression; and<\/li>\n
        3. the identification of the post-translational modifications controlling the function of the protein tyrosine-phosphatase DEP-1 in endothelial and cancer cells.<\/li>\n<\/ol>\n<\/div>\n\n

          Publications<\/h3>\n
            \n
          • Labrecque, L., Royal, I., Surprenant, D. S., Patterson, C., Gingras, D., and B\u00e9liveau, R. (2003) Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol. Biol. Cell 14: 334-347.<\/li>\n
          • Laram\u00e9e, M., Chabot, C., Cloutier, M., Stenne, R., Holgado-Madruga, M., Wong, A. and Royal, I. (2007) The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. J. Biol. Chem. 282: 7758-7769.<\/li>\n
          • Chabot, C., Spring, K., Gratton, J.P., Elchebly, M. and Royal, I. (2009) New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival. Mol. Cell. Biol. 29: 241-253.<\/li>\n
          • Caron, C., Spring, K., Laram\u00e9e, M., Chabot, C., Cloutier, M., Gu, H., and Royal, I. (2009) Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signaling, migration, and survival of endothelial cells. Cell. Signal. 21: 943-953.<\/li>\n
          • Spring, K., Chabot, C., Langlois, S., Trinh, T.N., Lapointe, L., Gavard, J., Elchebly, M. and Royal, I. (2011) Tyrosine phosphorylation of the carboxy-terminal tail of the protein tyrosine phosphatase DEP-1 as a mechanism controlling Src kinase activation, endothelial cell invasion, capillary formation and permeability. (En r\u00e9vision)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

            Coordonn\u00e9es Centre de recherche du CHUM H\u00f4pital Notre-Dame Pavillon J.A. de S\u00e8ve, Y4605 T 514 890-8000 #25497 F 514 412-7591 isabelle.royal@umontreal.ca Publications Labrecque, L., Royal, I., Surprenant, D. S., Patterson, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3695","page","type-page","status-publish","hentry"],"yoast_head":"\nRoyal, Isabelle, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/royal-isabelle-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Royal, Isabelle, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Centre de recherche du CHUM H\u00f4pital Notre-Dame Pavillon J.A. de S\u00e8ve, Y4605 T 514 890-8000 #25497 F 514 412-7591 isabelle.royal@umontreal.ca Publications Labrecque, L., Royal, I., Surprenant, D. 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