{"id":3685,"date":"2012-01-23T15:04:28","date_gmt":"2012-01-23T20:04:28","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/raymond-martine-ph-d\/"},"modified":"2013-08-16T16:10:00","modified_gmt":"2013-08-16T20:10:00","slug":"raymond-martine-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/raymond-martine-ph-d\/","title":{"rendered":"Raymond, Martine, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRIC – Universit\u00e9 de Montr\u00e9al
\nT<\/strong> 514 343-6746
\nF<\/strong> 514 343-6843
\nmartine.raymond@umontreal.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • G\u00e9nomique<\/li>\n
  • Approches th\u00e9rapeutiques<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n
  • Biologie des syst\u00e8mes<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    La membrane cellulaire dispose de prot\u00e9ines, dites \u00ab\u00a0transporteurs\u00a0\u00bb, qui ont pour fonction de transporter vers l\u2019ext\u00e9rieur de la cellule les compos\u00e9s cytotoxiques. Dans le cadre d\u2019un projet consacr\u00e9 aux m\u00e9canismes de r\u00e9sistance multiple aux m\u00e9dicaments, le laboratoire de la Dre Raymond \u00e9tudie la fonction des transporteurs de la famille ABC (ATP-binding cassette<\/em>) chez <\/em>la levure pathog\u00e8ne Candida albicans<\/em>. Son deuxi\u00e8me projet porte sur la g\u00e9nomique fonctionnelle de C. albicans<\/em>. Son \u00e9quipe a particip\u00e9 \u00e0 l\u2019annotation du g\u00e9nome de cette levure, un projet dirig\u00e9 par un groupe de l\u2019Institut de recherche en biotechnologie (IRB) du Conseil national de recherches du Canada. Les deux \u00e9quipes, dans le cadre d\u2019une collaboration, utilisent les puces \u00e0 ADN pour identifier les r\u00e9seaux transcriptionnels qui contr\u00f4lent le m\u00e9tabolisme, l\u2019hypoxie, ainsi que les processus de virulence et de r\u00e9sistance multiple aux m\u00e9dicaments chez cette levure.
    \n<\/div>\n

    \nPar ailleurs, la Dre Raymond cherche \u00e0 identifier de nouvelles prot\u00e9ines, impliqu\u00e9es dans les processus d\u2019ubiquitination ou de modification de la chromatine et susceptibles d\u2019\u00eatre cibl\u00e9es afin de d\u00e9velopper de nouveaux m\u00e9dicaments. Dans le cadre d\u2019une collaboration avec l\u2019\u00e9quipe du Dr Alain Verreault, ces chercheurs ont montr\u00e9 que la prot\u00e9ine Hst3, une d\u00e9ac\u00e9tylase de l\u2019histone H3 sp\u00e9cifique aux levures, est essentielle \u00e0 la croissance et la virulence de C. albicans<\/em>. Ces r\u00e9sultats constituent une premi\u00e8re \u00e9tape dans le d\u00e9veloppement de nouvelles th\u00e9rapies antifongiques ciblant la chromatine.
    \n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T 514 343-6746 F 514 343-6843 martine.raymond@umontreal.ca<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3685","page","type-page","status-publish","hentry"],"yoast_head":"\nRaymond, Martine, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/raymond-martine-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Raymond, Martine, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T 514 343-6746 F 514 343-6843 martine.raymond@umontreal.ca\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/raymond-martine-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2013-08-16T20:10:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/raymond-martine-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/raymond-martine-ph-d\/\",\"name\":\"Raymond, Martine, Ph.D. - 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