{"id":3681,"date":"2012-01-23T15:01:48","date_gmt":"2012-01-23T20:01:48","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/ramotar-dindial\/"},"modified":"2013-08-16T16:07:49","modified_gmt":"2013-08-16T20:07:49","slug":"ramotar-dindial","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/ramotar-dindial\/","title":{"rendered":"Ramotar, Dindial"},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Centre de recherche
\nH\u00f4pital Maisonneuve-Rosemont
\nT<\/strong> 514 252-3400 #4684
\nF<\/strong>\u00a0514 252-3430
\ndramotar@hmr.qc.ca<\/a><\/p>\n\n

\n

Description de la recherche<\/h2>\n

Caract\u00e9risation structurale et fonctionnelle des prot\u00e9ines d’eucaryotes qui r\u00e9parent sp\u00e9cifiquement les dommages \u00e0 l’ADN caus\u00e9s par les esp\u00e8ces r\u00e9actives oxyg\u00e9n\u00e9es. La prot\u00e9ine AP endonucl\u00e9ase\/3′- diesterase, Apn1, est une enzyme cl\u00e9 dans la voie de r\u00e9paration des dommages oxydatifs \u00e0 l’ADN de S. cerevisiae. Apn1 est n\u00e9cessaire pour r\u00e9parer les l\u00e9sions spontan\u00e9es \u00e0 l’ADN pour \u00e9liminer les alt\u00e9rations g\u00e9niques.
\n<\/div>\n

\n

Research description<\/h2>\n

Structural and functional characterization of protein that specifically repair DNA lesions that are caused by reactive oxygen species. The protein Apn1, with Ap endonuclease\/3′-diesterase activities, is a key enzyme in the repair of oxidative DNA lesions in S. cerevisiae. Apn1 is necessary to repair spontaneous DNA lesions to prevent genetic alterations.
\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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