{"id":3679,"date":"2013-07-26T13:34:49","date_gmt":"2013-07-26T17:34:49","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/pilon-nicolas-ph-d\/"},"modified":"2026-02-01T16:14:24","modified_gmt":"2026-02-01T21:14:24","slug":"pilon-nicolas-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/pilon-nicolas-ph-d\/","title":{"rendered":"Pilon, Nicolas, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Laboratoire de G\u00e9n\u00e9tique mol\u00e9culaire du d\u00e9veloppement
\nCentre de recherche BioMed
\nUniversit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM)
\n141 avenue Pr\u00e9sident-Kennedy
\nMontr\u00e9al, Qc, H2X 3Y7
\nT<\/strong> 514 987-3000 #3342
\nF<\/strong> 514 987-4647
\npilon.nicolas@uqam.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Cellules souches<\/li>\n
  • D\u00e9veloppement et diff\u00e9renciation tissulaire<\/li>\n
  • G\u00e9n\u00e9tique humaine et maladies g\u00e9n\u00e9tiques<\/li>\n
  • Neurobiologie<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Notre laboratoire s\u2019int\u00e9resse \u00e0 la g\u00e9n\u00e9tique mol\u00e9culaire du d\u00e9veloppement et plus particuli\u00e8rement aux cellules de la cr\u00eate neurale. Cette population de cellules souches engendre une multitude de types cellulaires diff\u00e9rents incluant\u00a0: neurones et glies p\u00e9riph\u00e9riques, m\u00e9lanocytes, ost\u00e9oblastes et chondrocytes cranio-faciaux ou encore certaines cellules sensorielles de l\u2019oreille interne. Nous utilisons la souris comme mod\u00e8le d\u2019\u00e9tude afin de d\u00e9cortiquer les m\u00e9canismes cellulaires et mol\u00e9culaires contr\u00f4lant la formation et la destin\u00e9e des cellules de la cr\u00eate neurale au cours du d\u00e9veloppement embryonnaire normal et pathologique. Nos travaux sont principalement regroup\u00e9s sous les deux axes suivants\u00a0:<\/p>\n

    1)\u00a0\u00a0\u00a0\u00a0\u00a0 Analyse du contr\u00f4le transcriptionnel de l\u2019induction des cellules de la cr\u00eate neurale.<\/p>\n

    2)\u00a0\u00a0\u00a0\u00a0\u00a0 Caract\u00e9risation de nouveaux mod\u00e8les de souris avec des d\u00e9fauts des cellules de la cr\u00eate neurale qui affectent les m\u00e9lanocytes, le syst\u00e8me nerveux ent\u00e9rique et\/ou l\u2019oreille interne.<\/p>\n

    Chaque projet implique l\u2019utilisation d\u2019un large \u00e9ventail de techniques de pointe en biologie mol\u00e9culaire et cellulaire ainsi que d\u2019approches ex vivo<\/i> et in vivo<\/i>.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Stem cells<\/li>\n
    • Development and tissue differentiation<\/li>\n
    • Human genetics and genetic diseases<\/li>\n
    • Neurobiology<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      Our laboratory is interested in the molecular genetics of development and most especially in neural crest cells. This particular stem cell population generates multiple different cell types including among others: peripheral neurons et glia, melanocytes, cranio-facial osteoblasts and chondrocytes as well as a subset of inner ear sensory cells. Using the mouse as a model organism, our goal is to decipher the molecular and cellular mechanisms underlying neural crest cell formation and fate during normal and pathological embryonic development. Our work is subdivided into two main projects:<\/p>\n

      1)\u00a0\u00a0\u00a0\u00a0\u00a0 Analyze the transcription control of neural crest cell induction.<\/p>\n

      2)\u00a0\u00a0\u00a0\u00a0\u00a0 Characterize new mouse models having neural crest cell defects affecting the melanocytes, the enteric nervous system and\/or the inner ear.<\/p>\n

      Each project involves a wide range of cutting edge molecular and cellular assays as well as ex vivo and in vivo approaches.<\/p>\n<\/div>\n

      <\/h3>\n","protected":false},"excerpt":{"rendered":"

      Coordonn\u00e9es Laboratoire de G\u00e9n\u00e9tique mol\u00e9culaire du d\u00e9veloppement Centre de recherche BioMed Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al (UQAM) 141 avenue Pr\u00e9sident-Kennedy Montr\u00e9al, Qc, H2X 3Y7 T 514 987-3000 #3342 F 514 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3679","page","type-page","status-publish","hentry"],"yoast_head":"\nPilon, Nicolas, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/pilon-nicolas-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pilon, Nicolas, Ph.D. - 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