{"id":3659,"date":"2012-01-23T14:13:06","date_gmt":"2012-01-23T19:13:06","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/meloche-sylvain-ph-d\/"},"modified":"2026-02-01T14:59:40","modified_gmt":"2026-02-01T19:59:40","slug":"meloche-sylvain-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/meloche-sylvain-ph-d\/","title":{"rendered":"Meloche, Sylvain Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRIC – Universit\u00e9 de Montr\u00e9al
\nT<\/strong>\u00a0 514 343-6966
\nF<\/strong>\u00a0 514 343-5839
\nsylvain.meloche@umontreal.ca<\/a>
\n<\/p>\n

\n

Axes de recherche<\/h2>\n
    \n
  • Canc\u00e9rologie<\/li>\n
  • Approches th\u00e9rapeutiques<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    M\u00e9canismes de signalisation contr\u00f4lant la prolif\u00e9ration des cellules normales et n\u00e9oplasiques: r\u00f4le de la phosphorylation et de la d\u00e9gradation par le prot\u00e9asome. Analyse biochimique et g\u00e9n\u00e9tique de la r\u00e9gulation et des fonctions des MAP kinases dans la prolif\u00e9ration et la diff\u00e9renciation cellulaire.\u00a0 R\u00e9gulation des inhibiteur des kinases d\u00e9pendantes des cyclines p21 et p27. D\u00e9couverte et validation de nouvelles cibles th\u00e9rapeutiques pour le cancer.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Cancer<\/li>\n
    • Therapeutic approaches<\/li>\n
    • Model systems in molecular biology<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      Signal transduction pathways controlling the proliferation of normal and transformed cells: role of phosphorylation and ubiquitin-mediated proteasome degradation. Biochemical and genetic analysis of the regulation and functions of MAP kinases in cell proliferation and differentiation.\u00a0 Regulation of the cyclin-dependent kinase inhibitors p21 and p27. Discovery and validation of novel cancer therapeutic targets.<\/p>\n<\/div>
      \n<\/p>\n","protected":false},"excerpt":{"rendered":"

      Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T\u00a0 514 343-6966 F\u00a0 514 343-5839 sylvain.meloche@umontreal.ca<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3659","page","type-page","status-publish","hentry"],"yoast_head":"\nMeloche, Sylvain Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/meloche-sylvain-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Meloche, Sylvain Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T\u00a0 514 343-6966 F\u00a0 514 343-5839 sylvain.meloche@umontreal.ca\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/meloche-sylvain-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-01T19:59:40+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/meloche-sylvain-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/meloche-sylvain-ph-d\/\",\"name\":\"Meloche, Sylvain Ph.D. - 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