{"id":3650,"date":"2012-02-02T14:21:17","date_gmt":"2012-02-02T19:21:17","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/mader-sylvie-ph-d\/"},"modified":"2013-08-16T16:01:44","modified_gmt":"2013-08-16T20:01:44","slug":"mader-sylvie-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/mader-sylvie-ph-d\/","title":{"rendered":"Mader, Sylvie, Ph.D."},"content":{"rendered":"

Chercheure principale<\/p>\n

Coordonn\u00e9es<\/h3>\n

IRIC<\/p>\n

T<\/strong> 514 343-7166
\nF<\/strong> 514 343-6843
\nsylvie.mader@umontreal.ca<\/a><\/p>\n\n

\n

Description de la recherche<\/h2>\n

Notre \u00e9quipe exploite des approches de g\u00e9nomique, prot\u00e9omique et bio-informatique pour identifier les voies de signalisation impliqu\u00e9es dans la tumorig\u00e9n\u00e8se de la glande mammaire gr\u00e2ce \u00e0 des mod\u00e8les de cellules en culture et de formation de tumeurs in vivo<\/em>. Nous utilisons \u00e9galement des approches de mod\u00e9lisation mol\u00e9culaire et d\u2019\u00e9tudes structurales pour concevoir de nouveaux m\u00e9dicaments dirig\u00e9s contre des cibles mol\u00e9culaires sp\u00e9cifiques. L\u2019activit\u00e9 de nouvelles mol\u00e9cules synth\u00e9tis\u00e9es par chimie m\u00e9dicinale en fonction des r\u00e9sultats de ces recherches peut ainsi \u00eatre test\u00e9e dans les mod\u00e8les exp\u00e9rimentaux utilis\u00e9s au laboratoire, qui incluent l\u2019isolation de cellules souches du cancer du sein. Des collaborations avec des chercheurs cliniciens, dont en particulier le Groupe de recherche en cancer du sein (GRCS) du Centre de recherche du CHUM (CRCHUM), nous permettent ultimement de tester les r\u00e9sultats de notre recherche fondamentale dans le cadre clinique de mani\u00e8re r\u00e9troactive ou prospective.<\/p>\n<\/div>\n

\n

Nous \u00e9tudions en particulier les voies de signalisation des r\u00e9cepteurs nucl\u00e9aires, des facteurs de transcription ligand-d\u00e9pendants qui sont des cibles id\u00e9ales pour le d\u00e9veloppement de m\u00e9dicaments. La dissection des m\u00e9canismes d\u2019action des r\u00e9cepteurs de oestrog\u00e8nes et de l\u2019acide r\u00e9tino\u00efque a permis de mieux comprendre les m\u00e9canismes de r\u00e9gulation de la structure de la chromatine et de la transcription par les ligands de ces r\u00e9cepteurs et de caract\u00e9riser les r\u00e9seaux de g\u00e8nes qu\u2019ils r\u00e9gulent ainsi que leurs r\u00f4les dans le contr\u00f4le de la diff\u00e9renciation et de la prolif\u00e9ration des cellules mammaires. Nos \u00e9tudes nous ont aussi permis de mieux comprendre les m\u00e9canismes d’action des compos\u00e9s utilis\u00e9s dans la th\u00e9rapie hormonale du cancer du sein, d\u2019identifier des marqueurs d\u2019efficacit\u00e9 de ces traitements et de concevoir de nouveaux compos\u00e9s th\u00e9rapeutiques plus performants dans des mod\u00e8les pr\u00e9-cliniques.<\/p>\n<\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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