Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n<\/ul>\nDescription de la recherche<\/h2>\n
Division et diff\u00e9renciation cellulaire.<\/strong> Notre \u00e9quipe de recherche utilise l’embryon du n\u00e9matode Caenorhabditis elegans<\/em> comme mod\u00e8le pour comprendre comment les ph\u00e9nom\u00e8nes de polarisation cellulaire peuvent conduire \u00e0 la division cellulaire asym\u00e9trique et \u00e0 la sp\u00e9cification de la diversit\u00e9 cellulaire. C. elegans<\/em> est un mod\u00e8le id\u00e9al pour \u00e9tudier ces probl\u00e8mes en raison des nombreux outils mol\u00e9culaires et g\u00e9n\u00e9tiques disponibles. \u00c9tant donn\u00e9 que la perte de polarit\u00e9 cellulaire peut mener au d\u00e9veloppement de m\u00e9tastases dans certaines conditions, ce travail permettra de mieux comprendre les voies de signalisation mol\u00e9culaires impliqu\u00e9es dans ce processus. De plus, la polarit\u00e9 cellulaire \u00e9tant cruciale pour la division de plusieurs types de cellules souches, ce travail procurera de nouvelles informations sur les m\u00e9canismes de renouvellement et de r\u00e9g\u00e9n\u00e9ration\u00a0cellulaires.<\/p>\n<\/div>\n\n
Research axis<\/h2>\n\n- Intracellular signaling<\/li>\n
- Mitosis<\/li>\n
- Stem cells<\/li>\n
- Model systems in molecular biology<\/li>\n<\/ul>\n
Research description<\/h2>\n
Cell Division and differentiation.<\/strong> Our research team uses the Caenorhabditis elegans<\/em> 1-cell embryo as a model to understand how establishment of polarity can lead to asymmetric cell division and specification of cell fates. C. elegans<\/em> is an ideal model to study these problems because of the numerous molecular and genetic tools available. Since loss of cell polarity can lead to metastasis in certain conditions, this work will allow a better understanding of the molecular pathways that prevent metastasis. Likewise, because polarity establishment and maintenance is crucial for stem cell division, this will provide new information on the processes of stem cell renewal and\u00a0regeneration.<\/div>\n\n","protected":false},"excerpt":{"rendered":"Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T 514 343-7893 F 514 343-6843 jc.labbe@umontreal.ca<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3639","page","type-page","status-publish","hentry"],"yoast_head":"\n
Labb\u00e9, Jean-Claude, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/labbe-jean-claude-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Labb\u00e9, Jean-Claude, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T 514 343-7893 F 514 343-6843 jc.labbe@umontreal.ca\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/labbe-jean-claude-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-01T19:33:48+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/labbe-jean-claude-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/labbe-jean-claude-ph-d\/\",\"name\":\"Labb\u00e9, Jean-Claude, Ph.D. - 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