Biologie des syst\u00e8mes<\/li>\n<\/ul>\nDescription de la recherche<\/h2>\n
La survie et le d\u00e9veloppement d\u2019organismes comme l\u2019\u00eatre humain d\u00e9pendent de multiples divisions cellulaires r\u00e9ussies; en fait, dans le cas de l\u2019\u00eatre humain, des centaines de billions de divisions. Les chercheurs observent la division cellulaire depuis plus d\u2019un si\u00e8cle et continuent d\u2019explorer les d\u00e9tails mol\u00e9culaires de ce processus fascinant. Lors de la division cellulaire, l\u2019un des grands objectifs consiste \u00e0 r\u00e9partir de fa\u00e7on \u00e9gale notre mat\u00e9riel h\u00e9r\u00e9ditaire entre deux cellules-filles. Cette t\u00e2che est assur\u00e9e par une machine complexe form\u00e9e de nombreux \u00e9l\u00e9ments, que l\u2019on appelle le fuseau mitotique. Comprendre les m\u00e9canismes mol\u00e9culaires qui sous-tendent les assemblages de cette machine est la base de notre recherche. Nous utilisons une approche multi-disciplinaire qui associe la biochimie des prot\u00e9ines, la biologie cellulaire et la microscopie \u00e0 haute r\u00e9solution pour \u00e9tudier la formation du fuseau dans les cultures de cellules de vert\u00e9br\u00e9s et dans des essais de reconstitution in vitro<\/em>.<\/p>\nL\u2019inhibition de l\u2019assemblage du fuseau mitotique bloque la progression du cycle des cellules et repr\u00e9sente une strat\u00e9gie efficace dans le traitement du cancer. Les prot\u00e9ines motrices de la superfamille de la kin\u00e9sine jouent des r\u00f4les importants dans l\u2019orchestration de la formation du fuseau. Leur capacit\u00e9 de contr\u00f4ler directement la structure des microtubules et la dynamique de la polym\u00e9risation les place dans une nouvelle cat\u00e9gorie de cibles chimioth\u00e9rapeutiques. Notre unit\u00e9 de recherche se concentre sur:<\/p>\n
\n- l\u2019\u00e9claircissement des m\u00e9canismes mol\u00e9culaires par lesquels les moteurs de la kin\u00e9sine et autres prot\u00e9ines associ\u00e9es aux microtubules contribuent au maintien du fuseau mitotique et<\/li>\n
- le d\u00e9veloppement de petits outils chimiques mol\u00e9culaires qui peuvent \u00eatre utilis\u00e9s dans la recherche biom\u00e9dicale et \u00e9ventuellement comme produits chimioth\u00e9rapeutiques dans la lutte contre le cancer.<\/li>\n<\/ol>\n<\/div>\n
\n
Research axis<\/h2>\n\n- Mitosis<\/li>\n
- Cancer<\/li>\n
- Therapeutic Approaches<\/li>\n
- Systems Biology<\/li>\n<\/ul>\n
Research description<\/h2>\n
The survival and development of organisms like humans rely on multiple rounds of successful cell divisions; in fact hundreds of trillion rounds for humans. Scientists have observed cell division for over a century and are still exploring the molecular details of this intriguing process. During cell division, a major goal is to partition our genetic material equally into two daughter cells. This task is carried by a complex, multi-component machine, called the mitotic spindle. Understanding the molecular mechanisms underlying the assembly of this machine is the basis of our research program. We use a multi-disciplinary approach that combines protein biochemistry, cell biology and high resolution microscopy to study spindle formation in cultured vertebrate cells and in in vitro<\/em> reconstitution assays.<\/p>\nInhibition of mitotic spindle assembly blocks cell cycle progression and is an effective strategy to treat cancer. Motor proteins in the kinesin superfamily play important roles in orchestrating spindle formation. Their ability to directly regulate microtubule organization and polymerization dynamics places them in a new class of chemotherapeutic targets.\u00a0 Our research unit focuses on the following two themes:<\/p>\n
\n- elucidating the molecular mechanisms by which kinesin motors and other microtubule-associated proteins contribute to mitotic spindle assembly, and<\/li>\n
- \u00a0developing small molecule chemical tools that can be used in biomedical research and potentially as anti-cancer chemotherapeutics.<\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
Principal Investigator Chemical Biology of Cell Division Research Unit Institute for Research in Immunology and\u00a0Cancer Research Assistant Professor Department of medicine Faculty of medicine Universit\u00e9 de Montr\u00e9al Coordonn\u00e9es IRIC T […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3638","page","type-page","status-publish","hentry"],"yoast_head":"\n
Kwok, Benjamin, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/kwok-benjamin-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kwok, Benjamin, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Principal Investigator Chemical Biology of Cell Division Research Unit Institute for Research in Immunology and\u00a0Cancer Research Assistant Professor Department of medicine Faculty of medicine Universit\u00e9 de Montr\u00e9al Coordonn\u00e9es IRIC T […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/kwok-benjamin-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2013-08-16T19:58:52+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/kwok-benjamin-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/kwok-benjamin-ph-d\/\",\"name\":\"Kwok, Benjamin, Ph.D. - 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