{"id":3628,"date":"2012-01-20T09:01:08","date_gmt":"2012-01-20T14:01:08","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/hoang-trang-ph-d\/"},"modified":"2026-02-01T14:23:37","modified_gmt":"2026-02-01T19:23:37","slug":"hoang-trang-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hoang-trang-ph-d\/","title":{"rendered":"Hoang, Trang, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRIC – Universit\u00e9 de Montr\u00e9al
\nT<\/strong> 514 343-6970
\nF<\/strong> 514 343-6945
\ntrang.hoang@umontreal.ca<\/a><\/p>\n

www.hoanglab.org<\/a>
\n<\/p>\n

\n

Axes de recherche<\/h2>\n
    \n
  • Interactions prot\u00e9iques<\/li>\n
  • Immunologie et H\u00e9matopo\u00ef\u00e8se<\/li>\n
  • Cellules souches<\/li>\n
  • Canc\u00e9rologie<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n
  • Biologie des syst\u00e8mes<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Notre objectif est de d\u00e9finir les interactions mol\u00e9culaires d\u00e9terminantes pour le devenir des cellules h\u00e9matopo\u00ef\u00e9tiques par des approches fonctionnelles, g\u00e9n\u00e9tiques et prot\u00e9omiques.\u00a0 Nous nous int\u00e9ressons en particulier aux processus mol\u00e9culaires de leuc\u00e9mogen\u00e8se induits par les facteurs de transcription oncog\u00e9niques ainsi qu\u2019\u00e0 la biologie des cellules souches h\u00e9matopo\u00ef\u00e9tiques normales et leuc\u00e9miques. Nous avons d\u00e9fini les complexes prot\u00e9iques fonctionnels assembl\u00e9s par les facteurs de transcription oncog\u00e9niques au niveau mol\u00e9culaire ainsi que les \u00e9v\u00e9nements g\u00e9n\u00e9tiques requis pour transformer une cellule normale en cellule initiatrice de leuc\u00e9mie. Nous avons adopt\u00e9 une approche pluridisciplinaire bas\u00e9e sur l\u2019\u00e9tude des souris transg\u00e9niques et des souris g\u00e9n\u00e9tiquement d\u00e9ficientes (knock-out) comme mod\u00e8le g\u00e9n\u00e9tique du cancer. Les approches exp\u00e9rimentales incluent des techniques de prot\u00e9omiques et g\u00e9nomiques, de transfert g\u00e9nique, de transplantation et de cytom\u00e9trie en flux.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Protein interactions<\/li>\n
    • Immunology and hematopoiesis<\/li>\n
    • Stem cells<\/li>\n
    • Cancer<\/li>\n
    • Model systems in molecular biology<\/li>\n
    • Systems biology<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      The objective of our work is to define key molecular interactions that control cell fate in the hematopoietic system by functional, genetic and proteomic approaches and how these interactions are subverted in leukemia. In particular, we are interested in oncogenic transcription factors and the biology of hematopoietic stem cells (HSC) as well as leukemic stem cells. We have defined protein complexes that are assembled by oncogenic transcription factors at the molecular level as well as the set of transforming events that are required to turn a normal cell into a leukemia-initating cells at the genetic level.\u00a0 We have adopted a multidisciplinary approach based on studies of transgenic and knock-out mice as genetic models of cancer. Experimental approaches include proteomics, genomics, gene transfer, stem cell transplantation and flow cytometry.<\/p>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"

      Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T 514 343-6970 F 514 343-6945 trang.hoang@umontreal.ca www.hoanglab.org<\/p>\n","protected":false},"author":25,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3628","page","type-page","status-publish","hentry"],"yoast_head":"\nHoang, Trang, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hoang-trang-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hoang, Trang, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T 514 343-6970 F 514 343-6945 trang.hoang@umontreal.ca www.hoanglab.org\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hoang-trang-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-01T19:23:37+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hoang-trang-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hoang-trang-ph-d\/\",\"name\":\"Hoang, Trang, Ph.D. - 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