{"id":3627,"date":"2012-02-09T11:40:15","date_gmt":"2012-02-09T16:40:15","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/david-r-hipfner-ph-d\/"},"modified":"2013-08-16T15:56:38","modified_gmt":"2013-08-16T19:56:38","slug":"david-r-hipfner-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/david-r-hipfner-ph-d\/","title":{"rendered":"Hipfner, David R., Ph. D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRCM
\nT<\/strong> 514 987-5508
\nF<\/strong> 514 987-5591
\ndavid.hipfner@ircm.qc.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Signalisation intracellulaire<\/li>\n
  • D\u00e9veloppement et diff\u00e9renciation tissulaire<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Les travaux du laboratoire visent \u00e0 identifier et caract\u00e9riser des m\u00e9canismes qui contr\u00f4lent la prolif\u00e9ration, la survie et l\u2019organisation des cellules \u00e9pith\u00e9liales durant le d\u00e9veloppement animal. Pour ce faire, on utilise la mouche des fruits, Drosophila melanogaster, comme syst\u00e8me mod\u00e8le g\u00e9n\u00e9tiquement mall\u00e9able. On profite ainsi d\u2019une vaste panoplie de puissantes techniques de g\u00e9n\u00e9tique mol\u00e9culaire disponibles pour ce mod\u00e8le, et de la sensibilit\u00e9 de ce dernier aux analyses biologiques et biochimiques, pour \u00e9tudier les diff\u00e9rents processus \u00e9nonc\u00e9s ci-dessus dans un contexte physiologique.<\/p>\n

    Le but vis\u00e9 est l\u2019apport de connaissances sur les m\u00e9canismes de base indispensables \u00e0 la formation, \u00e0 la croissance et au modelage des tissus \u00e9pith\u00e9liaux pendant le d\u00e9veloppement\u00a0 embryonnaire. Vu le r\u00f4le primordial que joue la d\u00e9r\u00e9gulation de la prolif\u00e9ration, de la survie et de l\u2019organisation cellulaires dans le cancer, on esp\u00e8re ainsi acqu\u00e9rir une meilleure compr\u00e9hension des m\u00e9canismes impliqu\u00e9s dans la formation des tumeurs et des m\u00e9tastases chez l\u2019humain.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Intracellular signalling<\/li>\n
    • Development and tissue differentiation<\/li>\n
    • Model systems in molecular biology<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      The research interests in the lab centre around the identification and characterization of mechanisms that control proliferation, survival, and organization of epithelial cells during animal development. To do so, we are using the fruit fly Drosophila melanogaster as a genetically tractable model system. We take advantage of the wide array of powerful molecular genetic techniques that are available with flies and their amenability to cell biological and biochemical analyses to study these processes in a physiological context.<\/p>\n

      Our goal is to provide insights into the basic mechanisms that are critical for the establishment, growth, and shaping of epithelial tissues during embryonic development. Given the central role of de-regulated cell proliferation, survival, and epithelial organization in cancer, we also expect to gain a better understanding of mechanisms involved in tumour formation and metastasis in humans.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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