Canc\u00e9rologie<\/li>\n<\/ul>\nDescription de la recherche<\/h2>\n
Nous cherchons \u00e0 comprendre les m\u00e9canismes mol\u00e9culaires de la division cellulaire, en particulier la cytocin\u00e8se, qui partitionne physiquement une cellule en deux. La cytocin\u00e8se est un processus spectaculaire impliquant de nombreuses branches de la biologie cellulaire: elle est int\u00e9gr\u00e9e dans le cycle cellulaire, et elle se produit gr\u00e2ce aux interactions dynamiques entre les membranes cellulaires et les diff\u00e9rents \u00e9l\u00e9ments du cytosquelette: les microtubules, l’actine, la myosine, les septines. Un r\u00e9seau de prot\u00e9ines conserv\u00e9s par l’\u00e9volution est connu pour contr\u00f4ler la cytocin\u00e8se, mais comment ce r\u00e9seau fonctionne r\u00e9ellement est mal comprise. Il est crucial de comprendre les d\u00e9tails mol\u00e9culaires de la fa\u00e7on comment la cytocin\u00e8se est ex\u00e9cut\u00e9 parce que les d\u00e9fauts dans le processus peuvent mener au cancer et la machinerie est \u00e9galement une cible potentielle pour de nouvelles th\u00e9rapies anti-canc\u00e9reuses.<\/p>\n
Nous utilisons des techniques de pointe en biologie cellulaire et mol\u00e9culaire, de la biochimie et de la g\u00e9n\u00e9tique pour diss\u00e9quer les m\u00e9canismes de la cytocin\u00e8se et son contr\u00f4le pendant le d\u00e9veloppement normal et, potentiellement, la canc\u00e9rogen\u00e8se. Notre syst\u00e8me principal de choix est l’utilisation de cellules en culture de la mouche \u00e0 fruit, Drosophila melanogsater<\/i>. Ces cellules profit d\u2019un g\u00e9nome simple, elles sont faciles \u00e0 manipuler g\u00e9n\u00e9tiquement et elles sont extr\u00eamement bien adapt\u00e9es \u00e0 la microscopie par fluorescence \u00e0 temps r\u00e9el. En outre, nos r\u00e9sultats sont directement pertinents pour comprendre la cytocin\u00e8se des cellules humaines.<\/p>\n
Des variations de la cytocin\u00e8se se produisent au cours du d\u00e9veloppement. Par exemple, les cellules souches se divisent de fa\u00e7on asym\u00e9trique pour produire des cellules filles avec des destins diff\u00e9rents. Nous sommes \u00e9galement int\u00e9ress\u00e9s \u00e0 la fa\u00e7on dont ces diff\u00e9rences peuvent \u00eatre expliqu\u00e9es par le m\u00e9canisme de la cytokin\u00e8se et nous travaillons \u00e0 tester ceci in vivo<\/i> chez la mouche.<\/p>\n<\/div>\n\n
Research axis<\/h2>\n\n- Cell division<\/li>\n
- Model systems in molecular and cell biology<\/li>\n
- Development<\/li>\n
- Cancer<\/li>\n<\/ul>\n
Research description<\/h2>\n
We aim to understand the molecular mechanisms of cell division, in particular cytokinesis, which physically partitions one cell into two. Cytokinesis is a spectacular process involving many branches of cell biology: it is integrated into the cell cycle, and it requires dynamic interplay between cell membranes and the different filament-forming elements of the cytoskeleton: microtubules, actin, myosin, septins.\u00a0 An evolutionarily conserved network of proteins is known to control cytokinesis, but how the network actually operates is poorly understood. It’s crucial to understand the molecular details of how cytokinesis is executed as defects in the process can give rise to cancer and the machinery is also a potential target for novel anti-cancer therapies.<\/p>\n
We employ cutting-edge techniques in molecular cell biology, biochemistry and genetics to dissect the mechanisms of cytokinesis and its control during both normal development and, potentially, cancer progression. Our main system of choice is the use of cultured cells from the fruitfly, Drosophila melanogsater<\/i>. These cells benefit from a simple genome, they are easy to manipulate genetically and they are extremely well suited to live-cell fluorescence microscopy. Furthermore, our findings are directly relevant to understanding cytokinesis of human cells.<\/p>\n
Variations of cytokinesis occur throughout development. For example, stem cells divide asymmetrically to produce daughter cells with different fates. We are also interested in how such differences might be accounted for by the core cytokinesis machinery and we are working towards testing this in vivo<\/i> in the fly.<\/p>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"
Coordonn\u00e9es Chercheur, Axe maladies virales, immunitaires et cancers Centre de Recherche du CHU Sainte-Justine, Montr\u00e9al Professeur Adjoint (sous octroi), Dept. Pathologie et Biologie cellulaire, Universit\u00e9 de Montr\u00e9al T 514 345-2189 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3626","page","type-page","status-publish","hentry"],"yoast_head":"\n
Hickson, Gilles, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hickson, Gilles, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Chercheur, Axe maladies virales, immunitaires et cancers Centre de Recherche du CHU Sainte-Justine, Montr\u00e9al Professeur Adjoint (sous octroi), Dept. Pathologie et Biologie cellulaire, Universit\u00e9 de Montr\u00e9al T 514 345-2189 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-01T19:19:12+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/\",\"name\":\"Hickson, Gilles, Ph.D. - Programmes de biologie mol\u00e9culaire\",\"isPartOf\":{\"@id\":\"https:\/\/biomol.umontreal.ca\/#website\"},\"datePublished\":\"2013-07-26T17:25:43+00:00\",\"dateModified\":\"2026-02-01T19:19:12+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Our professors\",\"item\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Hickson, Gilles, Ph.D.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/biomol.umontreal.ca\/#website\",\"url\":\"https:\/\/biomol.umontreal.ca\/\",\"name\":\"Programmes de biologie mol\u00e9culaire\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/biomol.umontreal.ca\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hickson, Gilles, Ph.D. - Programmes de biologie mol\u00e9culaire","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/","og_locale":"en_US","og_type":"article","og_title":"Hickson, Gilles, Ph.D. - Programmes de biologie mol\u00e9culaire","og_description":"Coordonn\u00e9es Chercheur, Axe maladies virales, immunitaires et cancers Centre de Recherche du CHU Sainte-Justine, Montr\u00e9al Professeur Adjoint (sous octroi), Dept. Pathologie et Biologie cellulaire, Universit\u00e9 de Montr\u00e9al T 514 345-2189 […]","og_url":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/","og_site_name":"Programmes de biologie mol\u00e9culaire","article_modified_time":"2026-02-01T19:19:12+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/","url":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/","name":"Hickson, Gilles, Ph.D. - Programmes de biologie mol\u00e9culaire","isPartOf":{"@id":"https:\/\/biomol.umontreal.ca\/#website"},"datePublished":"2013-07-26T17:25:43+00:00","dateModified":"2026-02-01T19:19:12+00:00","breadcrumb":{"@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/hickson-gilles-ph-d\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/biomol.umontreal.ca\/en\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/biomol.umontreal.ca\/en\/research\/"},{"@type":"ListItem","position":3,"name":"Our professors","item":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/"},{"@type":"ListItem","position":4,"name":"Hickson, Gilles, Ph.D."}]},{"@type":"WebSite","@id":"https:\/\/biomol.umontreal.ca\/#website","url":"https:\/\/biomol.umontreal.ca\/","name":"Programmes de biologie mol\u00e9culaire","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/biomol.umontreal.ca\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/comments?post=3626"}],"version-history":[{"count":4,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3626\/revisions"}],"predecessor-version":[{"id":6732,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3626\/revisions\/6732"}],"up":[{"embeddable":true,"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/pages\/3557"}],"wp:attachment":[{"href":"https:\/\/biomol.umontreal.ca\/en\/wp-json\/wp\/v2\/media?parent=3626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}