{"id":3614,"date":"2012-09-07T15:32:05","date_gmt":"2012-09-07T19:32:05","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/estall-jennifer-ph-d\/"},"modified":"2026-02-01T13:51:21","modified_gmt":"2026-02-01T18:51:21","slug":"estall-jennifer-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/estall-jennifer-ph-d\/","title":{"rendered":"Estall, Jennifer, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRCM
\n110, avenue des Pins Ouest
\nMontr\u00e9al (QC) – H2W1R7
\nT<\/strong> 514 987-5688
\njennifer.estall@ircm.qc.ca<\/a>
\n<\/p>\n

 <\/p>\n

\n

Axes de recherche<\/h2>\n
    \n
  • Endocrinologie<\/li>\n
  • Maladies cardiovasculaires<\/li>\n
  • Approches th\u00e9rapeutiques<\/li>\n
  • Organismes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Le diab\u00e8te touche des millions de personnes \u00e0 travers le monde et devient rapidement un lourd fardeau pour notre syst\u00e8me de sant\u00e9. Bien que les cons\u00e9quences du diab\u00e8te sur la sant\u00e9 globale soient bien identifi\u00e9es, ses signes pr\u00e9curseurs et leur \u00e9volution dans les organes\/cellules touch\u00e9s, pouvant mener \u00e0 une pathologie, demeurent mal compris au stade mol\u00e9culaire. De plus, les biomarqueurs permettant de d\u00e9tecter avec certitude une anomalie pr\u00e9coce dans un organe sont rares, ce qui limite notre capacit\u00e9 de pr\u00e9voir le d\u00e9veloppement des maladies avant l\u2019apparition de sympt\u00f4mes.<\/p>\n

    Le diab\u00e8te est caus\u00e9 par des anomalies de l\u2019hom\u00e9ostasie \u00e9nerg\u00e9tique cellulaire. \u00c0 l\u2019aide de mod\u00e8les g\u00e9n\u00e9tiques, des techniques de biochimie, de prot\u00e9omique et d\u2019analyses des voies critiques d\u2019expression g\u00e9nique, notre laboratoire tente d\u2019identifier les mol\u00e9cules cl\u00e9s impliqu\u00e9es dans le d\u00e9veloppement du diab\u00e8te et d\u2019autres maladies m\u00e9taboliques. Nous concentrons nos efforts pour comprendre comment le d\u00e9r\u00e8glement du m\u00e9tabolisme contribue \u00e0 la destruction des cellules b\u00eata qui produisent l\u2019insuline dans le pancr\u00e9as et \u00e0 la st\u00e9atose h\u00e9patique, deux maladies jouant un r\u00f4le majeur dans l\u2019aggravation du diab\u00e8te. Nous sommes particuli\u00e8rement int\u00e9ress\u00e9s par le r\u00f4le que jouent conjointement l\u2019environnement et la g\u00e9n\u00e9tique pour prot\u00e9ger contre la maladie ou la d\u00e9t\u00e9riorer.<\/p>\n

    Nos objectifs :<\/p>\n

      \n
    1. Mieux comprendre les changements mol\u00e9culaires qui surviennent dans les tissus malades.<\/li>\n
    2. Identifier de nouveaux facteurs mol\u00e9culaires et des programmes g\u00e9n\u00e9tiques importants pour l\u2019il\u00f4t de Langerhans et la fonction h\u00e9patique.<\/li>\n
    3. Identifier de nouvelles cibles th\u00e9rapeutiques dans le but de pr\u00e9venir la maladie ou d\u2019en diminuer la progression.<\/li>\n<\/ol>\n<\/div>\n
      \n

      Research axis<\/h2>\n
        \n
      • \u00a0Endocrinology<\/li>\n
      • Cardiovascular diseases<\/li>\n
      • Therapeutic approaches<\/li>\n
      • Model systems in molecular biology<\/li>\n<\/ul>\n

        Research description<\/h2>\n

        Diabetes affects millions of people worldwide and is rapidly becoming a significant burden on our health care system. While the impact of diabetes on overall health is well characterized; the initiating signals and steps within affected organs\/cells leading to pathology remain poorly understood at the molecular level. In addition, biomarkers that reliably detect early organ dysfunction are rare, limiting our ability to predict disease development prior to symptom appearance.<\/p>\n

        Diabetes is caused by abnormalities in energy homeostasis at the cellular level. Using genetic models, biochemistry, proteomics, and gene expression pathway analysis, our lab focuses on identifying key molecules implicated in the onset of diabetes and other metabolic diseases. We focus our efforts toward understanding how deregulated metabolism contributes to the destruction of insulin-producing beta-cells in the pancreas and fatty liver disease, two pathologies that play major roles in the severity of diabetes. We have a particular interest in how environment and genetics work together to either protect against or worsen disease.<\/p>\n

        Our goals are to:<\/p>\n

          \n
        1. Better understand the molecular changes that occur within diseased tissues;<\/li>\n
        2. Identify new molecular factors and genetic programs important for islet and liver function;<\/li>\n
        3. Reveal new therapeutic targets in an effort to prevent or lessen disease progression.<\/li>\n<\/ol>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"

          Coordonn\u00e9es IRCM 110, avenue des Pins Ouest Montr\u00e9al (QC) – H2W1R7 T 514 987-5688 jennifer.estall@ircm.qc.ca  <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3614","page","type-page","status-publish","hentry"],"yoast_head":"\nEstall, Jennifer, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/estall-jennifer-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Estall, Jennifer, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es IRCM 110, avenue des Pins Ouest Montr\u00e9al (QC) – H2W1R7 T 514 987-5688 jennifer.estall@ircm.qc.ca  \" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/estall-jennifer-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-01T18:51:21+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/estall-jennifer-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/estall-jennifer-ph-d\/\",\"name\":\"Estall, Jennifer, Ph.D. - 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