{"id":3611,"date":"2012-01-20T16:30:20","date_gmt":"2012-01-20T21:30:20","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/emery-gregory-ph-d\/"},"modified":"2013-08-16T15:52:25","modified_gmt":"2013-08-16T19:52:25","slug":"emery-gregory-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/emery-gregory-ph-d\/","title":{"rendered":"Emery, Gregory, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRIC – Universit\u00e9 de Montr\u00e9al
\nT<\/strong> 514 343-6111 #0318
\nF<\/strong> 514 343-6843
\ngregory.emery@umontreal.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Signalisation intracellulaire<\/li>\n
  • D\u00e9veloppement et diff\u00e9renciation tissulaire<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Le transport v\u00e9siculaire a longtemps \u00e9t\u00e9 consid\u00e9r\u00e9 comme un simple m\u00e9canisme de transport pour les prot\u00e9ines. Cette vision a chang\u00e9 radicalement et le transport v\u00e9siculaire est d\u00e9sormais connu comme \u00e9tant impliqu\u00e9 dans beaucoup d’\u00e9v\u00e9nements d\u00e9veloppementaux cl\u00e9s, tels que la signalisation cellulaire ou l’\u00e9tablissement de la polarit\u00e9 cellulaire, tout comme dans la formation des tumeurs.<\/p>\n

    Notre groupe utilise principalement la mouche drosophile Drosophila melanogaster comme syst\u00e8me mod\u00e8le pour \u00e9tudier comment le transport v\u00e9siculaire r\u00e9gule la signalisation cellulaire, en phase de d\u00e9veloppement. Notre int\u00e9r\u00eat actuel est la division cellulaire asym\u00e9trique, processus fondamental pour la g\u00e9n\u00e9ration de la diversit\u00e9 cellulaire, et utilis\u00e9 par certaines cellules souches pour s’auto-renouveler.<\/p>\n

    Un r\u00e9cepteur essentiel de signalisation en division cellulaire asym\u00e9trique est l’oncog\u00e8ne et tumoro-suppresseur “Notch”. Notch est conserv\u00e9 chez les mammif\u00e8res et impliqu\u00e9 dans plusieurs d\u00e9cisions cellulaires cruciales. La compr\u00e9hension de la r\u00e9gulation de Notch est par cons\u00e9quent tr\u00e8s importante et une partie consid\u00e9rable de nos efforts est dirig\u00e9e vers l’identification de la machinerie v\u00e9siculaire r\u00e9gulant Notch durant la division cellulaire asym\u00e9trique chez la drosophile. Notre groupe s’int\u00e9resse aussi \u00e0 v\u00e9rifier la conservation chez les mammif\u00e8res des r\u00e9gulateurs r\u00e9cemment identifi\u00e9s chez la mouche.<\/p>\n

    En outre, nous \u00e9tendrons notre \u00e9tude du r\u00f4le du trafic v\u00e9siculaire \u00e0 d’autres \u00e9v\u00e9nements de signalisation, en nous concentrant d’abord sur la migration cellulaire, un processus impliqu\u00e9 dans la formation des m\u00e9tastases.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Intracellular signaling<\/li>\n
    • Development and tissue differentiation<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      For a long time vesicular trafficking has been regarded only as a transport mechanism for proteins. However this view has dramatically evolved and vesicular trafficking is now known to be involved in many key developmental events like cell signalling and the establishment of cell polarity, but also in tumor formation.<\/p>\n

      Our group is using mainly the fruitfly (Drosophila melanogaster) as a model system to study how vesicular trafficking regulates cell signalling during development. Our current focus is asymmetric cell division, a fundamental process to generate cell diversity and used by certain stem cells to self-renew. One of the key signalling receptor in asymmetric cell division is the oncogene and tumor supressor Notch. Notch is conserved in mammals and involved in many cell fate decisions.<\/p>\n

      The understanding of the regulation of Notch is thus very important and a large part of our efforts is directed in the identification of the vesicular machinery regulating Notch during asymmetric cell division in Drosophila.<\/p>\n

      Our group is also interested to verify if newly identified regulators of Notch signalling are functionally conserved in mammals. Furthermore, we will extend our study of the role of vesicular trafficking to other signalling events, with an initial focus on cell migration, a process involved in metastasis formation.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T 514 343-6111 #0318 F 514 343-6843 gregory.emery@umontreal.ca<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3611","page","type-page","status-publish","hentry"],"yoast_head":"\nEmery, Gregory, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/emery-gregory-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Emery, Gregory, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es IRIC – Universit\u00e9 de Montr\u00e9al T 514 343-6111 #0318 F 514 343-6843 gregory.emery@umontreal.ca\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/emery-gregory-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2013-08-16T19:52:25+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/emery-gregory-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/emery-gregory-ph-d\/\",\"name\":\"Emery, Gregory, Ph.D. - 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