{"id":3606,"date":"2012-01-20T13:48:51","date_gmt":"2012-01-20T18:48:51","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/drouin-jacques-d-sc\/"},"modified":"2013-08-16T15:51:17","modified_gmt":"2013-08-16T19:51:17","slug":"drouin-jacques-d-sc","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/drouin-jacques-d-sc\/","title":{"rendered":"Drouin, Jacques, D.Sc."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRCM
\nT<\/strong> 514 987-5680
\nF<\/strong> 514 987-5575
\njacques.drouin@ircm.qc.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • D\u00e9veloppement et diff\u00e9renciation tissulaire<\/li>\n
  • G\u00e9nomique<\/li>\n
  • Endocrinologie<\/li>\n
  • G\u00e9n\u00e9tique humaine et maladies g\u00e9n\u00e9tiques<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Nous \u00e9tudions les m\u00e9canismes transcriptionnels et \u00e9pig\u00e9n\u00e9tiques qui contr\u00f4lent le passage de cellules prog\u00e9nitrices \u00e0 diff\u00e9renci\u00e9es en utilisant autant les outils de la g\u00e9nomique que de la biologie mol\u00e9culaire, la g\u00e9n\u00e9tique humaine et la manipulation g\u00e9n\u00e9tique chez la souris. Le cycle cellulaire est \u00e9tudi\u00e9 au cours de l\u2019organogen\u00e8se hypophysaire autant pour ses m\u00e9canismes d\u00e9veloppementaux qu\u2019hormonaux ainsi que dans la perspective de la r\u00e9sistance hormonale qui accompagne le d\u00e9veloppement de tumeurs hypophysaires chez l\u2019homme (maladie de Cushing). Les m\u00e9canismes de survie cellulaire sont aussi \u00e9tudi\u00e9s dans les neurones dopaminergiques qui d\u00e9g\u00e9n\u00e8rent dans la maladie de Parkinson. Enfin, les m\u00e9canismes d\u2019identit\u00e9 cellulaire sont \u00e9tudi\u00e9s dans les membres (identit\u00e9 jambes versus bras) au cours du d\u00e9veloppement.
    \n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Development and tissue differentiation<\/li>\n
    • Genomic<\/li>\n
    • Endocrinology<\/li>\n
    • Human genetics and genetic diseases<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      We study transcriptional and epigenetic mechanisms that control the transition from progenitor to differentiated cells using the tools of genomics, molecular biology, human genetics and gene manipulation in mice. We study the cell cycle during pituitary organogenesis in order to identify control mechanisms that are involved in development as well as in response to hormones: these studies are translated into understanding the hormone resistance that characterizes pituitary tumors in man (Cushing\u2019s disease). The mechanisms of cell survival are also investigated in the dopaminergic neurons that degenerate in Parkinson disease. Finally, mechanisms governing cell identity are also studied in limbs (hind- versus forelimb identity) for their patterning role in development.
      \n<\/div>\n","protected":false},"excerpt":{"rendered":"

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