{"id":3603,"date":"2013-06-13T16:29:48","date_gmt":"2013-06-13T20:29:48","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/di-noia-javier-ph-d\/"},"modified":"2026-02-01T13:46:35","modified_gmt":"2026-02-01T18:46:35","slug":"di-noia-javier-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/di-noia-javier-ph-d\/","title":{"rendered":"Di Noia, Javier, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Institut de Recherches Cliniques de Montr\u00e9al
\n110 avenue Des Pins Ouest
\nH2W 1R7 Montr\u00e9al
\nT<\/strong> 514 987-5642
\njavier.di.noia@ircm.qc.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Canc\u00e9rologie<\/li>\n
  • Immunologie et h\u00e9matopo\u00ef\u00e8se<\/li>\n
  • Syst\u00e8mes mod\u00e8les en biologie mol\u00e9culaire<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Nous \u00e9tudions les m\u00e9canismes par lesquels les g\u00e8nes d’anticorps sont diversifi\u00e9s pour lutter efficacement contre les infections. En particulier, nous nous int\u00e9ressons \u00e0 l\u2019hypermutation somatique (SHM) et \u00e0 la recombinaison de commutation de classe (CSR), deux processus qui sont d\u00e9clench\u00e9s apr\u00e8s qu\u2019un lymphocyte B reconnaisse son antig\u00e8ne correspondant. SHM introduit des mutations ponctuelles au niveau des g\u00e8nes d’anticorps, ce qui se traduira par des changements dans l’affinit\u00e9 pour l’antig\u00e8ne correspondant. Les cellules qui acqui\u00e8rent des mutations am\u00e9liorant la liaison seront s\u00e9lectionn\u00e9es et pr\u00e9vaudront dans la population. CSR produit l’\u00e9change des diff\u00e9rentes cassettes dans le g\u00e8ne de la cha\u00eene lourde d’immunoglobuline, ce qui d\u00e9finissent de nouvelles classes d’anticorps (IgG, IgE, IgE). Ensemble, SHM et CSR am\u00e9liorent grandement la r\u00e9ponse immunitaire.<\/p>\n

    L’enzyme \u00ab\u00a0Activation Induced Deaminase\u00a0\u00bb (AID) introduit des mutations et induit des cassures de l’ADN dans les g\u00e8nes d’anticorps pour initier SHM et la CSR. Nous nous int\u00e9ressons particuli\u00e8rement aux m\u00e9canismes mol\u00e9culaires qui r\u00e9gulent AID. Lorsqu\u2019AID est d\u00e9r\u00e9gul\u00e9e de quelque mani\u00e8re que ce soit, cela peut conduire \u00e0 une immunod\u00e9ficience ou faciliter l’auto-immunit\u00e9. En outre, comme effet secondaire de la diversification g\u00e9nique anticorps, AID peut initier ou contribuer \u00e0 la progression des lymphomes et \u00e0 la leuc\u00e9mie. Nous utilisons une combinaison de techniques mol\u00e9culaires, biochimiques, cellulaires, et des mod\u00e8les animaux dans notre recherche.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Cancer<\/li>\n
    • Immunology and Hematopo\u00efesis<\/li>\n
    • Intracellular signaling<\/li>\n
    • Model Systems in Molecular Biology<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      We study the mechanisms by which the antibody genes are diversified to efficiently fight infections. In particular we are interested in somatic hypermutation (SHM) and class switch recombination (CSR), two processes that are triggered after a B cell engages cognate antigen through membrane-bound antibodies. SHM introduces point mutation at the antibody genes, which will translate into changes in the affinity for the cognate antigen. Those cells acquiring mutations that improve the binding will be selected and prevail in the population. CSR mediates the exchange of different cassettes within the immunoglobulin heavy chain gene that define new antibody classes (IgG, IgE, IgE). Together, SHM and CSR greatly improve the antibody response and permit the elimination of the infection.<\/p>\n

      The enzyme Activation Induced Deaminase (AID) introduces mutations and induces DNA breaks at the antibody genes to generate genetic diversity to initiates SHM and CSR. We are particularly interested in the molecular mechanisms that regulate AID When AID is deregulated in any way it can lead to immunodeficiency or facilitate autoimmunity. Moreover, as a side effect of antibody gene diversification AID can initiate or contribute to lymphoma and leukemia. We use a combination of molecular, biochemical, cellular, and in vivo techniques in our research.<\/p>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"

      Coordonn\u00e9es Institut de Recherches Cliniques de Montr\u00e9al 110 avenue Des Pins Ouest H2W 1R7 Montr\u00e9al T 514 987-5642 javier.di.noia@ircm.qc.ca<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3603","page","type-page","status-publish","hentry"],"yoast_head":"\nDi Noia, Javier, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/di-noia-javier-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Di Noia, Javier, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Institut de Recherches Cliniques de Montr\u00e9al 110 avenue Des Pins Ouest H2W 1R7 Montr\u00e9al T 514 987-5642 javier.di.noia@ircm.qc.ca\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/di-noia-javier-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-01T18:46:35+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/di-noia-javier-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/di-noia-javier-ph-d\/\",\"name\":\"Di Noia, Javier, Ph.D. - 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