G\u00e9nomique fonctionnelle int\u00e9grative des traits cardiovasculaires complexes<\/strong><\/p>\n<\/strong>Les techniques de g\u00e9n\u00e9tique traditionnelle ont permis d\u2019identifier des nombreuses variations g\u00e9n\u00e9tiques responsables de maladies h\u00e9r\u00e9ditaires \u00e0 transmission mend\u00e9lienne. Malgr\u00e9 leur gravit\u00e9, ce type de maladies (o\u00f9 une variation de la s\u00e9quence d\u2019un seul g\u00e8ne est g\u00e9n\u00e9ralement \u00e0 elle seule suffisante pour expliquer la maladie), est cependant relativement rare. En opposition aux maladies \u00e0 transmission mend\u00e9lienne, les maladies plus communes qui affectent une grande partie de la population (comme par exemple les maladies cardiovasculaires) sont consid\u00e9r\u00e9es comme des \u00ab\u00a0maladies complexes\u00a0\u00bb, o\u00f9 la pr\u00e9disposition g\u00e9n\u00e9tique r\u00e9sulte d\u2019interactions entre de tr\u00e8s nombreux g\u00e8nes.<\/p>\nPour \u00e9lucider les d\u00e9terminants g\u00e9n\u00e9tiques de traits cardiovasculaires complexes, nous \u00e9tudions des croisements g\u00e9n\u00e9tiques animaux \u00e0 l\u2019aide de nouvelles techniques de g\u00e9nomique fonctionnelle int\u00e9grative. Cette approche utilise des outils bio-informatiques pour int\u00e9grer diverses informations biologiques, incluant les variations g\u00e9n\u00e9tiques existant au niveau du g\u00e9nome entier, l\u2019expression g\u00e9nique tissulaire et les fonctions des g\u00e8nes, pour comprendre comment certaines interactions g\u00e9niques complexes peuvent conduire \u00e0 l\u2019apparition de certains traits ph\u00e9notypiques cardiovasculaires.<\/p>\n<\/div>\n
\n
Research axis<\/h2>\n\n- Genomic<\/li>\n
- Bioinformatics<\/li>\n
- Cardiovascular diseases<\/li>\n
- Human genetics and genetic diseases<\/li>\n<\/ul>\n
Research description<\/h2>\n
Functional integrative genomics of complex cardiovascular traits<\/strong><\/p>\nTraditional genetics techniques have made it possible to identify numerous genetic variations responsible for hereditary Mendelian diseases. Despite their severity, such diseases (where a variation of the sequence of one single gene is usually sufficient to explain occurrence of the disease) are relatively rare. In contrast, more common diseases that affect large segments of the population (such as for instance cardiovascular diseases) are considered as being \u201ccomplex diseases\u201d, where genetic predisposition is the result of interactions between a great number of genes.<\/p>\n
To decipher the genetic determinants of complex cardiovascular traits, we study genetic animal crosses using new and developing techniques of functional integrative genomics. To do this, we use bioinformatics tools to integrate various kinds of biologic information, including whole genome genetic variations, tissue gene expression and gene functions to elucidate how complex genetic interactions may lead to the development of certain cardiovascular phenotypic traits.<\/p>\n<\/div>\n\n
Publications<\/h3>\n\n- LLAMAS B, B\u00c9LANGER S., PICARD S., and DESCHEPPER CF. <\/strong>\u00a0Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in mice.\u00a0 Physiol. Genomics<\/em>, 31: 176\u2013182, 2007.<\/li>\n
- M. KHAIRALLAH, R. KHAIRALLAH, M.E. YOUNG, B.G. ALLEN, M.A. GILLIS, G. DANIALOU, C.F. DESCHEPPER,<\/strong> B.J. PETROF, C. DES ROSIERS.\u00a0 Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency.\u00a0 Proc. Natl. Ac. Sci<\/em>., 105:7028-33, 2008.<\/li>\n
- B. LLAMAS, R. VERDUGO, G.A. CHURCHILL and C.F. DESCHEPPER.<\/strong>\u00a0 Chromosome Y variants from different mouse inbred strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone.\u00a0 BMC Genomics<\/em>, 10: 150, 2009.<\/li>\n
- R.A. VERDUGO, C.F. DESCHEPPER<\/strong>, G. MU\u00d1OZ, D. POMP, and G.A. CHURCHILL.\u00a0 Importance of randomization in microarray experimental designs with Illumina platforms.\u00a0 Nucl. Ac. Res. <\/em>37:5610-8, 2009.<\/li>\n
- MP SCOTT-BOYER, A. TAYEB, G.C IMHOLTE, A. LABBE, C.F. DESCHEPPER<\/strong>, R. GOTTARDO.\u00a0 An Integrated Hierarchical Bayesian Model for Multivariate eQTL Mapping.\u00a0 Submitted to Statistical Applications in Genetics and Molecular Biology<\/em>, 2012.<\/em><\/li>\n<\/ul>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Coordonn\u00e9es Institut de recherches cliniques de Montr\u00e9al 110, avenue des Pins Ouest Montr\u00e9al (Qu\u00e9bec)\u00a0Canada\u00a0H2W 1R7 T 514 987-5759 F 514 987-5585 christian.deschepper@ircm.qc.ca Publications LLAMAS B, B\u00c9LANGER S., PICARD S., and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3602","page","type-page","status-publish","hentry"],"yoast_head":"\n
Deschepper, Christian F., M.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/deschepper-christian-f-m-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Deschepper, Christian F., M.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Institut de recherches cliniques de Montr\u00e9al 110, avenue des Pins Ouest Montr\u00e9al (Qu\u00e9bec)\u00a0Canada\u00a0H2W 1R7 T 514 987-5759 F 514 987-5585 christian.deschepper@ircm.qc.ca Publications LLAMAS B, B\u00c9LANGER S., PICARD S., and […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/deschepper-christian-f-m-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2013-08-16T19:50:25+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/deschepper-christian-f-m-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/deschepper-christian-f-m-d\/\",\"name\":\"Deschepper, Christian F., M.D. - 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