{"id":3598,"date":"2012-01-19T23:00:06","date_gmt":"2012-01-20T04:00:06","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/cote-jean-francois-ph-d\/"},"modified":"2026-02-01T13:40:56","modified_gmt":"2026-02-01T18:40:56","slug":"cote-jean-francois-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/cote-jean-francois-ph-d\/","title":{"rendered":"C\u00f4t\u00e9, Jean-Fran\u00e7ois, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

IRCM
\nT<\/strong> 514 987-5647
\nF<\/strong> 514 987-5624
\nJean-Francois.Cote@ircm.qc.ca<\/a>
\n<\/p>\n

\n

Axes de recherche<\/h2>\n
    \n
  • Interactions prot\u00e9iques<\/li>\n
  • Signalisation intracellulaire<\/li>\n
  • D\u00e9veloppement et diff\u00e9renciation tissulaire<\/li>\n
  • Canc\u00e9rologie<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    La r\u00e9organisation dynamique et constante du squelette d\u2019actine permet les changements d\u2019apparence, de ronde jusqu\u2019\u00e0 allong\u00e9e, que peuvent adopter les cellules.\u00a0 Ces m\u00e9tamorphoses cellulaires sont essentielles dans des processus biologiques normaux tels que la motilit\u00e9 cellulaire et le d\u00e9veloppement des muscles et des reins. Au niveau du cancer, le remodelage du squelette cellulaire est directement impliqu\u00e9 dans la diss\u00e9mination m\u00e9tastatique, un \u00e9v\u00e8nement destructeur mettant en jeu la survie des patients.<\/p>\n

    Le Dr Jean-Fran\u00e7ois C\u00f4t\u00e9 s\u2019int\u00e9resse \u00e0 comprendre les voies de signalisation qui contr\u00f4lent la migration cellulaire principalement via la r\u00e9organisation du cytosquelette d\u2019actine. Un des projets principaux de son laboratoire est centr\u00e9 sur l\u2019\u00e9tude du complexe prot\u00e9ique DOCK180\/ELMO et de l\u2019activation de Rac dans la r\u00e9organisation du cytosquelette menant \u00e0 la migration directionnelle des cellules. Ces prot\u00e9ines sont essentielles \u00e0 plusieurs processus physiologiques mais sont aussi directement impliqu\u00e9es dans la motilit\u00e9 des cellules canc\u00e9reuses. Les \u00e9tudes de son unit\u00e9 sont multidisciplinaires (approches biochimiques, cellulaires, g\u00e9n\u00e9tiques et structurales) ayant comme objectif de diss\u00e9quer les m\u00e9canismes mol\u00e9culaires contr\u00f4lant l\u2019organisation du cytosquelette. Dans le cancer, la migration cellulaire, commun\u00e9ment appel\u00e9e invasion pour les cellules canc\u00e9reuses, contribue de fa\u00e7on majeure \u00e0 la progression de tumeurs au stade m\u00e9tastatique. Les oncog\u00e8nes HER-2 et Axl sont fr\u00e9quemment mut\u00e9s et\/ou amplifi\u00e9s dans le cancer du sein. De telles tumeurs positives pour HER-2 et Axl sont souvent meurtri\u00e8res : elles sont agressives et m\u00e9tastatiques. Son unit\u00e9 de recherche \u00e9tudie donc les voies de signalisation promouvant une telle invasion cellulaire avec pour but d\u2019identifier des cibles pharmacologiques pour traiter ces tumeurs invasives.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • protein interactions<\/li>\n
    • intracellular signaling<\/li>\n
    • development and tissue differenciation<\/li>\n
    • cancer<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      The dynamic and constant reorganization of the actin skeleton leads to changes in the appearance of cells, from round to elongated. These cell metamorphoses are essential to normal biological processes like cell motility and muscle and kidney development. In cancer, remodelling of the cell skeleton is directly involved in metastasis, a destructive event that puts patients\u2019 survival at risk.<\/p>\n

      Dr. C\u00f4t\u00e9 is interested in understanding signalling pathways that control cell migration, primarily through the reorganization of the actin cytoskeleton. One of the team\u2019s major projects focuses on the protein complex DOCK180\/ELMO and the activation of Rac in cytoskeletal reorganization, leading to the directional migration of cells. These proteins are essential to various physiological processes and are also directly involved in the motility of cancer cells. The unit is engaged in multidisciplinary studies using biochemical, cellular, genetic and structural approaches, with the objective of dissecting the molecular mechanisms that control cytoskeletal organization. In cancer, cell migration, commonly known as invasion by cancer cells, makes a substantial contribution to the progression of tumours to the metastatic stage. The oncogens HER-2 and Axl are frequently mutated and\/or amplified in breast cancer. Tumours that test positive for HER-2 and Axl are frequently fatal, as they are aggressive and metastatic. The team is studying the signalling pathways that promote this cell invasion with the aim of identifying pharmacologic targets for treating these invasive tumours.<\/p>\n<\/div>
      \n<\/p>\n","protected":false},"excerpt":{"rendered":"

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