{"id":3586,"date":"2011-12-01T16:30:29","date_gmt":"2011-12-01T21:30:29","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/bradley-edward-ph-d\/"},"modified":"2013-08-16T15:18:13","modified_gmt":"2013-08-16T19:18:13","slug":"bradley-edward-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bradley-edward-ph-d\/","title":{"rendered":"Bradley, Edward, Ph.D."},"content":{"rendered":"

Professeur titulaire
\nD\u00e9partement de m\u00e9decine
\nUniversit\u00e9 de Montr\u00e9al<\/p>\n

Coordonn\u00e9es<\/h3>\n

Centre de recherche du CHUM
\nH\u00f4pital Notre-Dame, pavillon J.A. deS\u00e8ve
\n1560 Sherbrooke est
\nMontr\u00e9al (Qu\u00e9bec) H2L 4M1
\nT<\/strong> 514 890-8000 #23438
\nF<\/strong> 514 412-7591
\nedward.bradley@umontreal.ca<\/a>
\n<\/p>\n

\n

Axes de recherche<\/h2>\n
    \n
  • G\u00e9nomique<\/li>\n
  • Canc\u00e9rologie<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Nous \u00e9tudions les changements qui arrivent au niveau de la chromatine lors du d\u00e9veloppement de cancer. Chez les cellules normales, le contr\u00f4le de la conformation de la chromatine est relativement stable, mais chez les cancers on observe une \u00e9talement de le structure ferm\u00e9e ou ouverte, de sorte que des centaines de g\u00e8nes pourraient \u00eatre inacvtiv\u00e9s ou activ\u00e9s d\u2019une fa\u00e7on inappropri\u00e9e. En \u00e9tudiant ces \u00e9v\u00e9nements epigenetiques, on est en m\u00e9sure d\u2019identifier des g\u00e8nes impliqu\u00e9s dans le processus de canc\u00e9risation, et on peut \u00e9galement distinguer entre les g\u00e8nes qu\u2019on appele \u2018passengers\u2019 vs. \u2018drivers\u2019 \u2013 ces derniers \u00e9tant les vrais g\u00e8nes de cancer.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Genomic<\/li>\n
    • Cancer<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      We are studying changes occurring at the level of chromatin during cancer development.\u00a0 In normal cells, the control of chromatin conformation is relatively stable, but in cancer open or closed structures can spread, resulting in inappropriate activation or inactivation of hundreds of genes.\u00a0 By studying these changes, we can identify new cancer genes, and we can also distinguish between \u2018passengers\u2019 and \u2018drivers\u2019, the latter being the real cancer-associated genes.<\/p>\n<\/div>\n\n

      Publications<\/h3>\n
        \n
      • More is less: inactivation and deletion events and the search for tumor suppressor genes. Bradley WE, Di Paola D, Rampakakis E, Zannis-Hadjopoulos M. J Cell Biochem. 2010 May 15;110(2):281-7.<\/li>\n
      • Hotspots of large rare deletions in the human genome. Bradley WE, Raelson JV, Dubois DY, Godin E, Fournier H, Priv\u00e9 C, Allard R, Pinchuk V, Lapalme M, Paulussen RJ, Belouchi A. PLoS One. 2010 Feb 25;5(2):e9401.<\/li>\n
      • RARbeta involvement in enhancement of lung tumor cell immunogenicity revealed by array analysis. Toulouse A, Loubeau M, Morin J, Pappas JJ, Wu J, Bradley WE. FASEB J. 2000 Jun;14(9):1224-32.<\/li>\n
      • Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Houle B, Rochette-Egly C, Bradley WE. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):985-9.<\/li>\n
      • Mutation at autosomal loci of Chinese hamster ovary cells: involvement of a high-frequency event silencing two linked alleles. Bradley WE. Mol Cell Biol. 1983 Jul;3(7):1172-81.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        Professeur titulaire D\u00e9partement de m\u00e9decine Universit\u00e9 de Montr\u00e9al Coordonn\u00e9es Centre de recherche du CHUM H\u00f4pital Notre-Dame, pavillon J.A. deS\u00e8ve 1560 Sherbrooke est Montr\u00e9al (Qu\u00e9bec) H2L 4M1 T 514 890-8000 #23438 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3586","page","type-page","status-publish","hentry"],"yoast_head":"\nBradley, Edward, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bradley-edward-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bradley, Edward, Ph.D. - 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