{"id":3580,"date":"2011-12-01T15:31:19","date_gmt":"2011-12-01T20:31:19","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/bijl-janetta-ph-d\/"},"modified":"2013-08-16T15:15:16","modified_gmt":"2013-08-16T19:15:16","slug":"bijl-janetta-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bijl-janetta-ph-d\/","title":{"rendered":"Bijl, Janetta, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Centre de recherche H\u00f4pital Maisonneuve Rosemont
\n5415, boulevard de l’Assomption
\nMontr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada
\nT<\/strong> 514 252-3400 #5878
\nF<\/strong> 514 252-3569
\njanettabijl@yahoo.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Immunologie et h\u00e9matopo\u00ef\u00e8se<\/li>\n
  • Canc\u00e9rologie<\/li>\n
  • Cellules souches<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    La production des cellules de sang \u00e0 partir la cellule souche h\u00e9matopo\u00ef\u00e9tique est un processus complexe. Les g\u00e8nes homeobox (Hox) jouent un r\u00f4le important dans la r\u00e9gulation de ce processus. Quand ces g\u00e8nes sont erron\u00e9ment active, les cellules pouvant devenir malignes. En faite les g\u00e8nes Hox sont souvent activ\u00e9s dans les leuc\u00e9mies humaines. Afin de mieux comprendre le r\u00f4le qui jouent ces g\u00e8nes dans la pathogen\u00e8se de la leuc\u00e9mie c\u2019est important a comprendre leur fonction pr\u00e9cise dans la r\u00e9gulation du d\u00e9veloppement du sang. \u00c7a peut nous permettre de modul\u00e9e les cellules afin de les diriger a se d\u00e9velopper dans les cellules d\u00e9sires ou a expans\u00e9 des populations rare, qui peut \u00eatre utilis\u00e9e pour th\u00e9rapie cellulaire. Malheureusement, les \u00e9tudes effectu\u00e9es jusqu’\u00e0 maintenant n\u2019ont pas permis d\u2019identifier leur r\u00f4le pr\u00e9cis dans le d\u00e9veloppement du sang car il existe de la redondance fonctionnaire entre les g\u00e8nes Hox. Pour ce raison nous utilisons des souris mutante conditionnelle pour tous les g\u00e8nes HoxA permettons a \u00e9liminer les g\u00e8nes HoxA sp\u00e9cifique dans les cellules du sang.<\/p>\n

    Nous \u00e9tudions aussi l\u2019effet du surexpression du g\u00e8nes Hox sur expansion des cellules souches h\u00e9matopo\u00ef\u00e9tique (CSH) in vitro, car les nombres de ces cellules disponibles limitent le succ\u00e8s du transplantation du moelle osseuse. Une th\u00e9rapie qui est souvent utilis\u00e9e pour les patients \u00e9teint de la leuc\u00e9mie. Nous avons trouve que le g\u00e8ne Hoxa4 peut augment\u00e9e les nombre des CSH dans les souris. Bas\u00e9e sur les ressemblance entre les CSH et les cellules T m\u00e9moires (Tm), des cellules rares qui nous prot\u00e9gent contre les r\u00e9infections des pathog\u00e8nes, nous analysons si les g\u00e8nes Hox peuvent aussi augmenter le nombre des cellules Tm. Finalement nous \u00e9tudions si les g\u00e8nes de HoxA cluster sont essentiels dans a leuc\u00e9mie.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Immunology and haematopo\u00efesis<\/li>\n
    • Cancer<\/li>\n
    • Stem cells<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      The production of blood cells originating from the blood stem cells is a complex process. Homeobox (Hox) genes play an important role in the regulation of this process. When these regulatory genes are erroneous expressed cells can become malignant. Indeed high expression of Hox genes is frequently associated with human leukemias. To better understand their role in the pathogenesis of leukemia it is critical to understand their precise functions in blood cell development. This will allow us to manipulate hematopoietic cells to differentiate into desired populations or expand rare stem cell and progenitor populations for therapeutic purposes. Unfortunately, single gene knock-outs failed to identify their functions for reasons of redundancy between Hox genes. For that reason we are using a conditional knock-out mouse for all the HoxA genes, which allows us to specifically excise the HoxA genes in blood cells, to study the effect of HoxA deletion on blood cell generation.<\/p>\n

      Hox genes are highly expressed in blood stem cells and we are studying whether overexpression of these genes can expand the stem cell numbers in vitro, since the available number of stem cells are the limiting factor for successful bone marrow transplantation. This therapy is often used for leukemia patients. Using mice, we found that Hoxa4 can increase the blood stem cell numbers. Based on the similarities between blood stem cells and memory T cells (Tm), which are important in immune defense against pathogens, we are evaluating whether Hox gene overexpresion also lead to expansion of Tm cells. Finally, observations supporting a critical role for Hox genes in survival of leukemic cells have been reported and therefore, we are investigating whether leukemias are dependent on the presence of HoxA genes. These studies could lead to new drug treatments and therapy.<\/p>\n<\/div>\n\n

      Publications<\/h3>\n
        \n
      • Fournier M, Lebert-Ghali CE, Krosl G and Bijl JJ<\/strong>. HOXA4 induces expansion of hematopoietic stem cells in vitro and confers enhancement of pro-B-cells in vivo. Stem Cells & Development, 2011 in press.<\/li>\n
      • Lebert-Ghali CE, Fournier M, Thompson A, Dickson GJ, Sauvageau G and Bijl JJ<\/strong>. The HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells, Exp Hematology, 2010; 38\u00a0:1074-1086.<\/li>\n
      • Bijl JJ<\/strong>, Krosl J, Lebert-Ghali CE, Vacher J, Mayotte N and Sauvageau G. Hoxb4<\/em> collaborates with E2a<\/em>–PBX<\/em> in the induction of acute mouse T-cell leukemia. Oncogene<\/em>, 2008 Oct 23, 27: 6356-64<\/li>\n
      • Bijl JJ<\/strong>., Thompson A., Ramirez-Solis R, Krosl J. Grier D., Lawrence HJ and Sauvageau G. Analysis of HSC Activity and Compensatory Hox<\/em> Gene Expression Profile in Hoxb<\/em> Cluster Mutant Fetal Liver Cells. Blood<\/em>, 2006 July 1st<\/sup>, 108:116-122.<\/li>\n
      • Bijl JJ<\/strong>, Sauvageau M, Thompson A and Sauvageau G. High Incidence of Proviral Integrations in the Hoxa<\/em> Locus in a New Model of E2a-PBX1-Induced B-Cell Leukemia. Genes & Dev<\/em>. 2005 Jan 15; 19:224<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        Coordonn\u00e9es Centre de recherche H\u00f4pital Maisonneuve Rosemont 5415, boulevard de l’Assomption Montr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada T 514 252-3400 #5878 F 514 252-3569 janettabijl@yahoo.ca Publications Fournier M, Lebert-Ghali CE, Krosl […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3580","page","type-page","status-publish","hentry"],"yoast_head":"\nBijl, Janetta, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bijl-janetta-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bijl, Janetta, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Centre de recherche H\u00f4pital Maisonneuve Rosemont 5415, boulevard de l’Assomption Montr\u00e9al (Qu\u00e9bec) H1T 2M4 Canada T 514 252-3400 #5878 F 514 252-3569 janettabijl@yahoo.ca Publications Fournier M, Lebert-Ghali CE, Krosl […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bijl-janetta-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2013-08-16T19:15:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bijl-janetta-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bijl-janetta-ph-d\/\",\"name\":\"Bijl, Janetta, Ph.D. - 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