{"id":3578,"date":"2011-12-01T11:46:17","date_gmt":"2011-12-01T16:46:17","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/bertrand-richard-ph-d\/"},"modified":"2014-06-19T16:04:17","modified_gmt":"2014-06-19T20:04:17","slug":"bertrand-richard-ph-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bertrand-richard-ph-d\/","title":{"rendered":"Bertrand, Richard, Ph.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Centre de recherche – CHUM
\nInstitut du cancer de Montr\u00e9al
\n900 rue St-Denis, bureau R10.424
\nMontr\u00e9al, QC, H2X 0A9
\nT<\/strong> 514 890-8000 #26615
\nF<\/strong> 514 412-7591
\nrichard.bertrand@umontreal.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Canc\u00e9rologie<\/li>\n
  • Interactions prot\u00e9iques<\/li>\n
  • Signalisation intracellulaire<\/li>\n
  • Approches th\u00e9rapeutiques<\/li>\n<\/ul>\n

    Description de la recherche<\/h2>\n

    Recherche sur les m\u00e9canismes fondamentaux des r\u00e9ponses cellulaires et mol\u00e9culaires \u00e0 la chimioth\u00e9rapie anticanc\u00e9reuse.<\/p>\n

    Le laboratoire \u00e9tudie les m\u00e9canismes fondamentaux li\u00e9s au contr\u00f4le et \u00e0 la fonction des g\u00e8nes, prot\u00e9ines et voies de signalisation r\u00e9gulant la mort des cellules tumorales dite par apoptose, suite aux traitements de chimioth\u00e9rapie. Nous nous int\u00e9ressons plus particuli\u00e8rement \u00e0 un groupe de g\u00e8ne\/prot\u00e9ine de la famille de Bcl-2, et \u00e0 une cascade prot\u00e9olytique gouvern\u00e9e par l’activation d’une classe de prot\u00e9ases sp\u00e9cifiques, les caspases. L’implication de certaines organelles de la cellule, dont les mitochondries et les lysosomes, dans la r\u00e9gulation de la mort des cellules tumorales est \u00e9galement sous \u00e9tude. L’influence et la r\u00e9gulation exerc\u00e9es par certaines des prot\u00e9ines de la famille de Bcl-2 sur les points-contr\u00f4le du cycle cellulaire, est \u00e9galement investigu\u00e9 dans le laboratoire, plus particuli\u00e8rement la r\u00e9gulation de Bcl-xL dans les points-contr\u00f4le G2\/M et durant la mitose.<\/p>\n

    Des \u00e9tudes sur les m\u00e9canismes \u00e9pig\u00e9n\u00e9tiques stabilisant la s\u00e9nescence cellulaire induite par la chimioth\u00e9rapie, et sur l’influence des cycles circadiens dans les r\u00e9ponses \u00e0 la chimioth\u00e9rapie sont planifi\u00e9es dans le laboratoire.\u00a0 Finalement, de nouvelles strat\u00e9gies exp\u00e9rimentales anticanc\u00e9reuses sont \u00e9valu\u00e9es dans le laboratoire, en collaboration avec d’autres groupes de recherche.<\/p>\n<\/div>\n

    \n

    Research axis<\/h2>\n
      \n
    • Cancer<\/li>\n
    • Protein interactions<\/li>\n
    • Intracellular signaling<\/li>\n
    • Therapeutic approaches<\/li>\n<\/ul>\n

      Research description<\/h2>\n

      The cellular and molecular responses to genotoxic drugs used in anticancer chemotherapy are extremely varied and complex. Genotoxic drugs activate a series of responses involving gene activation, post-translational protein modifications and intracellular signalling pathways that mediate cell cycle arrest, cellular senescence and\/or cell death.<\/p>\n

      Research in the laboratory is focused on the control and function of genes, proteins and signalling pathways that regulate cell death by apoptosis, particularly on genes\/proteins of the Bcl-2 family, and on activation of a proteolytic cascade involving a class of specific proteases, the caspases.\u00a0 The importance of cellular organelles, including mitochondria and lysosomes, in the regulation of apoptosis is also investigated. The influence of Bcl-2 family members on cell-cycle checkpoints is also being investigated in the laboratory, particularly Bcl-xL regulation in the G2\/M and spindle-assembly checkpoints.<\/p>\n

      Research projects on the epigenetic changes associated with stabilization of cellular senescence, and on the influence of circadian rhythms on tumour responses to chemotherapy are also planned. Finally, new experimental anticancer therapeutic strategies are under investigation in the laboratory, in collaboration with other research groups.<\/p>\n<\/div>\n\n

      Publications<\/h3>\n
        \n
      • PARENT, N., WINSTALL, E., BEAUCHEMIN, M., PAQUET, C. POIRIER,G, BERTRAND R. Quantitative proteomic analysis of enriched lysosomes in camptothecin-induced apoptosis in human histiocytic lymphoma U937 cells, J Proteomics. 72:960-73, 2009.<\/li>\n
      • PARENT, N., SCHERER, M.,\u00a0 LIEBISCH, G., SCHMITZ, G., BERTRAND, R.,\u00a0 Protein kinase C-delta isoform mediates lysosome labilization in DNA damage-induced apoptosis, Int J Oncol, 38:313-324,2011.<\/li>\n
      • WANG, J., BEAUCHEMIN, M., BERTRAND, R., <\/strong>Bcl-xL phosphorylation at Ser49 by Polo kinase\u00a03 in cell cycle progression and checkpoints, Cell Signal 23: 2030-38, 2011.<\/li>\n
      • WANG, J., BEAUCHEMIN, M., BERTRAND, R., Phospho-Bcl-xL(ser62) plays a key role at the G2 checkpoint, Cell Cycle 11:2159-69, 2012.<\/li>\n
      • WANG, J., BEAUCHEMIN, M., BERTRAND, R., Phospho-Bcl-xL(ser62) influences spindle-assembly and chromosome segregation during mitosis, Cell Cycle 13:8 1313-1326, 2014.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        Coordonn\u00e9es Centre de recherche – CHUM Institut du cancer de Montr\u00e9al 900 rue St-Denis, bureau R10.424 Montr\u00e9al, QC, H2X 0A9 T 514 890-8000 #26615 F 514 412-7591 richard.bertrand@umontreal.ca Publications PARENT, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3578","page","type-page","status-publish","hentry"],"yoast_head":"\nBertrand, Richard, Ph.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bertrand-richard-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bertrand, Richard, Ph.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Centre de recherche – CHUM Institut du cancer de Montr\u00e9al 900 rue St-Denis, bureau R10.424 Montr\u00e9al, QC, H2X 0A9 T 514 890-8000 #26615 F 514 412-7591 richard.bertrand@umontreal.ca Publications PARENT, […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bertrand-richard-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2014-06-19T20:04:17+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bertrand-richard-ph-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/bertrand-richard-ph-d\/\",\"name\":\"Bertrand, Richard, Ph.D. - 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