{"id":3574,"date":"2013-07-25T11:39:29","date_gmt":"2013-07-25T15:39:29","guid":{"rendered":"https:\/\/biomol.umontreal.ca\/research\/professors\/berthiaume-yves-m-d\/"},"modified":"2013-11-20T14:28:55","modified_gmt":"2013-11-20T19:28:55","slug":"berthiaume-yves-m-d","status":"publish","type":"page","link":"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/berthiaume-yves-m-d\/","title":{"rendered":"Berthiaume, Yves, M.D."},"content":{"rendered":"

Coordonn\u00e9es<\/h3>\n

Institut de Recherches Cliniques de Montr\u00e9al
\n110 avenue Des Pins Ouest
\nH2W 1R7 Montr\u00e9al
\nT<\/strong> 514 987-5500 poste 3248
\nyves.berthiaume@ircm.qc.ca<\/a><\/p>\n\n

\n

Axes de recherche<\/h2>\n
    \n
  • Signalisation intracellulaire<\/li>\n
  • G\u00e9n\u00e9tique humaine et maladies g\u00e9n\u00e9tiques<\/li>\n
  • Approches th\u00e9rapeutiques<\/li>\n<\/ul>\n<\/div>\n
    \n

    Research axis<\/h2>\n
      \n
    • Intracellular signaling<\/li>\n
    • Human Genetic and Genetic Diseases<\/li>\n
    • Therapeutic approaches<\/li>\n<\/ul>\n<\/div>\n\n

      Description de la recherche<\/h3>\n

      Les int\u00e9r\u00eats de recherche du Dr Yves Berthiaume sont ax\u00e9s sur la pathogen\u00e8se de deux maladies respiratoires. Dans un premier temps, nous explorons le r\u00f4le de l\u2019\u00e9pith\u00e9lium pulmonaire dans la pathophysiologie de l\u2019\u0153d\u00e8me pulmonaire et des l\u00e9sions pulmonaires. Plus sp\u00e9cifiquement, nous \u00e9tudions l\u2019interaction entre la r\u00e9ponse inflammatoire et la dysfonction de l\u2019\u00e9pith\u00e9lium dans ces pathologies. Une de ces dysfonctions est une anomalie dans le transport des fluides au travers de l\u2019\u00e9pith\u00e9lium alv\u00e9olaire. Nous tentons d\u2019\u00e9lucider les m\u00e9canismes d\u2019expression (ARN messagers) du canal sodique ENaC et son activit\u00e9 dans les cellules \u00e9pith\u00e9liales soumises \u00e0 un stress inflammatoire pr\u00e9sent lors de ces atteintes pulmonaires. Nous explorons \u00e9galement le r\u00f4le des alarmines des mol\u00e9cules endog\u00e8nes associ\u00e9es aux l\u00e9sions cellulaires (Damage Associated Molecular Pattern ou DAMP) dans la modulation de ce transport ionique et \u00e9galement les processus de r\u00e9paration des l\u00e9sions \u00e9pith\u00e9liales pr\u00e9sentes dans les l\u00e9sions pulmonaires.<\/p>\n

      Notre deuxi\u00e8me axe de recherche est sur la fibrose kystique, une maladie h\u00e9r\u00e9ditaire causant des infections respiratoires chroniques ainsi qu\u2019une atteinte multisyst\u00e9mique secondaire \u00e0 une mutation dans le g\u00e8ne CFTR. Nos travaux les plus r\u00e9cents portent sur le r\u00f4le des m\u00e9canismes de r\u00e9gulation \u00e9pig\u00e9n\u00e9tiques dans l\u2019expression de g\u00e8nes qui pourraient aider \u00e0 expliquer les variations de la s\u00e9v\u00e9rit\u00e9 de la fibrose kystique. On explore plus particuli\u00e8rement le r\u00f4le de deux g\u00e8nes soit RGS2 et la Chitinase\u00a0-3\u2014 like. De plus, en collaboration avec le Dr R\u00e9mi Rabasa-Lhoret, nous sommes int\u00e9ress\u00e9s \u00e0 comprendre les m\u00e9canismes inflammatoires pouvant contribuer \u00e0 l\u2019\u00e9volution du diab\u00e8te chez ces patients, complication pr\u00e9sente chez plus de 40\u00a0% des patients adultes souffrant de fibrose kystique.<\/p>\n\n

      Publications<\/h3>\n
        \n
      • Dagenais A, Fr\u00e9chette R, Clermont M-E, Mass\u00e9 C, Priv\u00e9 A, Brochiero E, Berthiaume Y<\/b>. Dexamethasome inhibits the action of TNF on ENaC expression and Activity. Am J Physiol Lung Cell Mol Physiol\u00a0 <\/i>2006; 291: L1220-31.<\/li>\n
      • Boncoeur E, Tardif V, Tessier MC, Morneau F., Lavoie J, Gendreau-Berthiaume E, Grygorczyk R, Dagenais A, Berthiaume Y<\/b>. Modulation of epithelial sodium channel activity by lipopolysaccharide in alveolar type II cells: Involvement of purinergic signalling. <\/b>\u00a0Am J Physiol Lung Cell Mol Physiol<\/i>.<\/i> 298:L417-26, 2010.<\/li>\n
      • BoncoeurE, Bouvet G, Migneault F, Tardif V, Ferraro P, Govindaraju K, Radzioch D, De Sanctis JB, Dagenais A, Berthiaume Y<\/b>. <\/b>Induction of Nitric Oxide Synthase Expression By Lipopolysaccharide is Mediated by Calcium-dependent PKC in Alveolar Epithelial Cells. Am J Physiol<\/i> <\/i>2013; 305(2): L175-84<\/li>\n
      • Migneault F, Boncoeur E, Morneau F, Pascariu M, Dagenais A, Berthiaume Y<\/b>. Cycloheximide and Lipopolysaccharides downregulate \u03b1ENaC mRNA via different mechanisms in alveolar epithelial cells. Am J Physiol<\/i> 2013; 305(10):L747-55.<\/li>\n
      • Wright FA, Strug LJ, Doshi VK, Commander CW, Blackman SM, Sun L, Berthiaume Y<\/b>, Cutler D, Cojocaru A, Collaco JM, Corey M, Dorfman R, Goddard K, Green D, Kent JW Jr, Lange EM, Lee S, Li W, Luo J, Mayhew GM, Naughton KM, Pace RG, Par\u00e9 P, Rommens JM, Sandford A, Stonebraker JR, Sun W, Taylor C, Vanscoy LL, Zou F, Blangero J, Zielenski J, O’Neal WK, Drumm ML, Durie PR, Knowles MR, Cutting GR. Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. Nat Genet.<\/i> 2011;43:539-46.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        Coordonn\u00e9es Institut de Recherches Cliniques de Montr\u00e9al 110 avenue Des Pins Ouest H2W 1R7 Montr\u00e9al T 514 987-5500 poste 3248 yves.berthiaume@ircm.qc.ca Description de la recherche Les int\u00e9r\u00eats de recherche du […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3557,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-3574","page","type-page","status-publish","hentry"],"yoast_head":"\nBerthiaume, Yves, M.D. - Programmes de biologie mol\u00e9culaire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/berthiaume-yves-m-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Berthiaume, Yves, M.D. - Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"og:description\" content=\"Coordonn\u00e9es Institut de Recherches Cliniques de Montr\u00e9al 110 avenue Des Pins Ouest H2W 1R7 Montr\u00e9al T 514 987-5500 poste 3248 yves.berthiaume@ircm.qc.ca Description de la recherche Les int\u00e9r\u00eats de recherche du […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/berthiaume-yves-m-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Programmes de biologie mol\u00e9culaire\" \/>\n<meta property=\"article:modified_time\" content=\"2013-11-20T19:28:55+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/berthiaume-yves-m-d\/\",\"url\":\"https:\/\/biomol.umontreal.ca\/en\/research\/les-professeurs\/berthiaume-yves-m-d\/\",\"name\":\"Berthiaume, Yves, M.D. - 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